Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study

Author(s)

Addeo Cipolli, Jose Alexandre ^[1] ; Ferreira-Sae, Maria Carolina ^[1] ; Martins, Rafael Prado ^[1] ; Pio-Magalhaes, Jose Alexandre ^[1] ; Bellinazzi, Vera Regina ^[1] ; Matos-Souza, Jose Roberto ^[1] ; Nadruz Junior, Wilson ^{[2, 1]}

Affiliation

^[1] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, BR-13081970 Campinas, SP - Brazil

• Document type: Journal article
• Source: BMC CARDIOVASCULAR DISORDERS; v. 12, JUL 16 2012.
• Web of Science Citations: 29

Abstract

Background: The impact of serum uric acid (SUA) on arteries of hypertensive subjects remains to be fully established. This study investigated the relationship between SUA and carotid structural and hemodynamic parameters in hypertensive men and women. Methods: Three hundred and thirty eight patients (207 women and 131 men) were cross-sectionally evaluated by clinical, laboratory, hemodynamic and carotid ultrasound analysis. Common carotid diameters, circumferential wall tensions, Young's Elastic Modulus, Stiffness Index, Arterial Compliance and intima-media thickness (IMT) were determined. Internal carotid artery resistive index (ICRI), a hemodynamic measure that reflects local vascular impedance and microangiopathy, was also assessed. Results: Univariate analysis showed no significant correlation of SUA with carotid diameters, elasticity/stiffness indexes, IMT and circumferential wall tensions in both genders. Conversely, SUA correlated with ICRI (r = 0.34; p < 0.001) in women, but not in men, and hyperuricemic women presented higher ICRI than normouricemic ones (0.684 +/- 0.007 vs. 0.649 +/- 0.004; p < 0.001). Stepwise and logistic regression analyses adjusted for potential confounding factors showed that ICRI was independently associated with SUA and hyperuricemia in women. Conclusions: This study demonstrated that SUA was associated with ICRI in hypertensive women, suggesting that there might gender-related differences in the relationship between SUA and vascular damage in subjects with systemic hypertension. (AU)

• FAPESP's process: 10/16252-0 - Mechanisms related to increased cardiovascular risk in spinal cord injury subjects
• Grantee: Wilson Nadruz Junior
• Support Opportunities: Regular Research Grants