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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exploratory study of the effect of lifestyle counselling on bone mineral density and body composition in users of the contraceptive depot-medroxyprogesterone acetate

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Author(s):
Modesto, Waleska [1] ; Valeria Bahamondes, M. [1] ; dos Santos, Priscila Silva [1] ; Fernandes, Arlete [1] ; Dal'Ava, Natalia [1] ; Bahamondes, Luis [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Natl Inst Hormones & Womens Hlth, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE; v. 19, n. 4, p. 244-249, AUG 2014.
Web of Science Citations: 5
Abstract

Objectives To compare variations in bone mineral density (BMD) and body composition (BC) in depot-medroxyprogesterone acetate (DMPA) users and nonusers after providing counselling on healthy lifestyle habits. Methods An exploratory study in which women aged 18 to 40 years participated: 29 new DMPA users and 25 new non-hormonal contraceptive users. All participants were advised on healthy lifestyle habits: sun exposure, walking and calcium intake. BMD and BC were assessed at baseline and 12 months later. Statistical analysis included the Mann-Whitney test or Student's t-test followed by multiple linear regression analysis. Results Compared to the controls, DMPA users had lower BMD at vertebrae L1 and L4 after 12 months of use. They also had a mean increase of 2 kg in total fat mass and an increase of 2.2% in body fat compared to the non-hormonal contraceptive users. BMD loss at L1 was less pronounced in DMPA users with a calcium intake >= 1 g/day compared to DMPA users with a lower calcium intake. Conclusions DMPA use was apparently associated with lower BMD and an increase in fat mass at 12 months of use. Calcium intake >= 1 g/day attenuates BMD loss in DMPA users. Counselling on healthy lifestyle habits failed to achieve its aims. (AU)

FAPESP's process: 09/53293-0 - Prospective study for evaluation of the insulin resistance, lipid metabolism and sub clinical cardiovascular disease in women who initiate the depot-medroxyprogesterone acetate (DMP A) contraceptive method with in follow-up for two years. (Project of scientific research)
Grantee:Luis Guillermo Bahamondes
Support type: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
FAPESP's process: 11/01554-4 - Body composition and bone mineral density in users of depot medroxyprogesterone acetate compared to CIU Tcu380A Intrauterine Device
Grantee:Waleska Oliveira Modesto
Support type: Scholarships in Brazil - Doctorate