Effects of arm crank exercise training on cardiovascular function in patients with peripheral artery disease: a randomized controlled trial

• Grant number: 17/22113-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2019
• End date: January 31, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Nelson Wolosker
• Grantee: Nelson Wolosker
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
• Associated researchers: John Michael Saxton ; Marilia de Almeida Correia ; Nelson Wolosker ; Raphael Mendes Ritti Dias

Abstract

Peripheral arterial disease (PAD) patients have a high risk of fatal and nonfatal cardiovascular events due to cardiovascular disease. Thus, strategies that reduce cardiovascular risk in these patients are necessary. Studies with arm crank exercise (ACE) have observed improvement in functional capacity in patients with DAP bypassing the main barrier to exercise in these patients, the pain. However, the effect of this exercise training on cardiovascular function is not well established. The aim of this study is to analyze the effects of 12 weeks of ACE training on cardiovascular function in PAD patients, and compare it with treadmill exercise (TE), the actual recommendation for these patients. In this clinical trial, 45 patients will be allocated randomly in three experimental groups: ACE training, TE and control group. ACE and TE groups will perform exercises twice a week with the intensity equivalent to 13-15 on Borg's Subjective Perception Exertion Scale. Patients in control group will meet twice a week, however only to perform diverse activities and group living, without any type of exercise involved. All groups will be encouraged to increase their levels of activity, as they are usually guided in medical consultations. Before and after 12 weeks of intervention, the following cardiovascular function indicators will be obtained: brachial and central arterial pressures, heart rate variability, arterial stiffness and endothelial function. For statistical analysis, two-way analysis of variance for repeated measures will be conducted with the group (AE, TE and control) and time (pre- and post-intervention) as factor. Significance level will be set at Pd0.05. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KANEGUSUKU, HELCIO; CORREIA, MARILIA ALMEIDA; LONGANO, PAULO; RITTI-DIAS, RAPHAEL MENDES; WOLOSKER, NELSON; CUCATO, GABRIEL GRIZZO. Effects of arm-crank exercise on cardiovascular function, functional capacity, cognition and quality of life in patients with peripheral artery disease: Study protocol for a randomized controlled trial. PLoS One, v. 17, n. 5, p. 14-pg., 2022-05-05. (17/22113-2)