Musculoskeletal aging: metabolic and functional repercussions and mortality risk in people aged 50 and older

• Grant number: 18/13917-3
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: June 01, 2019
• End date: May 31, 2024
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Tiago da Silva Alexandre
• Grantee: Tiago da Silva Alexandre
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Cesar Messias de Oliveira
• Associated research grant(s): 24/22108-2 - 15th International Conference on Frailty and Sarcopenia Research & Geroscience Task Force, AR.EXT
• Associated scholarship(s): 22/09886-0 - Structuring and Organization of Databases, BP.TT; 21/11505-2 - Sarcopenia and dynapenia as risk factors for mobility decline in the elderly: an analysis with different cutoff points, BP.MS; 21/11142-7 - Do the reduction of forced vital capacity (FVC), of forced expiratory volume in the first second (FEV1) and the ratio FEV1/FVC reduce muscle strength in the elderly?, BP.MS; + associated scholarships 21/06169-3 - Structuring and Organization of Databases, BP.TT; 20/06716-1 - Incidence of low serum levels of Vitamin D in individuals with and without abdominal obesity, BP.IC; 20/02040-3 - Uncontrolled systemic arterial hypertension and diabetes accelerate the decline in memory and executive function in people over 50 years old?, BP.MS; 19/14699-2 - Structuring and organization of databases, BP.TT - associated scholarships

Abstract

There is a gap in the understanding of the relationship between abdominal obesity, low vitamin D serum levels and dynapenia later in life. However, there is strong evidence suggesting that these three conditions may be interconnected and part of the same mechanism that affects negatively musculoskeletal health and, consequently, metabolic and functional capacity later in life. Therefore, the objectives of the present proposal are: i) to analyze the incidence of dynapenia in individuals with and without vitamin D deficiency; ii) to analyze the incidence of low vitamin D serum levels in subjects with and without abdominal obesity; iii) to analyze the association between dynapenic abdominal obesity and the trajectory of metabolic disorders of carbohydrates, lipids, systemic arterial pressure, mobility disability and lower limbs functional limitation; iv) to analyze the association between dynapenic abdominal obesity and the incidence of metabolic syndrome and cardiovascular mortality. Data from the English Longitudinal Study of Ageing (ELSA), a long-term multi-cohort study that began in 2002 and has more than 15 years of follow-up, will be used. This project benefits from an existing research partnership between the candidate and the University College London (UCL). In order to answer each of the questions in this proposal, we will use incidence density analyzes, Poisson and logistic regression models, Kaplan-Meyer curves, Cox regression models and Generalized Linear Mixed Models. Our hypotheses are: i) the incidence of dynapenia is higher in individuals with low serum vitamin D levels; (ii) the incidence of low serum vitamin D levels is higher in obese individuals; and (iii) trajectories of lower limb function, mobility disability and changes in carbohydrate, lipid and blood pressure metabolism as well as the incidence of metabolic syndrome and mortality due to cardiovascular diseases are higher in obese individuals. (AU)

Scientific publications

(22)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COCHAR-SOARES, NATALIA; DE CARVALHO, DANILO H. T.; DE ANDRADE, FABIOLA B.; CASTRO-COSTA, ERICO; DE OLIVEIRA, CESAR; LIMA-COSTA, MARIA F.; ALEXANDRE, TIAGO DA S.. Does undiagnosed diabetes mitigate the association between diabetes and cognitive impairment? Findings from theELSI-Brazilstudy. JOURNAL OF DIABETES, JUL 2020. (17/22818-6, 18/13917-3)

BERNARDES SPEXOTO, MARIA CLAUDIA; RAMIREZ, PAULA CAMILA; MAXIMO, ROBERTA DE OLIVEIRA; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. European Working Group on Sarcopenia in Older People 2010 (EWGSOP1) and 2019 (EWGSOP2) criteria or slowness: which is the best predictor of mortality risk in older adults?. AGE AND AGEING, v. 51, n. 7, p. 10-pg., 2022-07-01. (18/13917-3)

MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, DAYANE CAPRA; CAMILA RAMIREZ, PAULA; LUIZ, MARIANE MARQUES; DE SOUZA, ALINE FERNANDA; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. ynapenia, abdominal obesity or both: which accelerates the gait speed decline most. AGE AND AGEING, v. 50, n. 5, p. 1616-1625, SEP 2021. (18/13917-3, 17/26377-4)

PEREIRA DA SILVA, THAIS BARROS; LUIZ, MARIANE MARQUES; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Is Abdominal Obesity a Risk Factor for the Incidence of Vitamin D Insufficiency and Deficiency in Older Adults? Evidence from the ELSA Study. NUTRIENTS, v. 14, n. 19, p. 10-pg., 2022-10-01. (18/13917-3, 20/06716-1)

DA SILVA, T. B. P.; LUIZ, M. M.; DELINOCENTE, M. L. B.; STEPTOE, A.; DE OLIVEIRA, C.; ALEXANDRE, T. S.. ABDOMINAL OBESITY AS A RISK FACTOR FOR THE INCIDENCE OF VITAMIN D INSUFFICIENCY AND DEFICIENCY. AGING CLINICAL AND EXPERIMENTAL RESEARCH, v. 35, p. 2-pg., 2023-07-01. (18/13917-3)

DELINOCENTE, M. L. B.; LUIZ, M. M.; OLIVEIRA, D. C.; SOUZA, A. F.; RAMIREZ, P. C.; OLIVEIRA, R. O.; COCHAR-SOARES, N.; STEPTOE, A.; OLIVEIRA, C.; ALEXANDRE, T. S.. ARE SERUM 25-HYDROXYVITAMIN D DEFICIENCY AND INSUFFICIENCY RISK FACTORS FOR THE INCIDENCE OF DYNAPENIA?. AGING CLINICAL AND EXPERIMENTAL RESEARCH, v. 34, n. SUPPL 1, p. 1-pg., 2022-09-01. (18/13917-3, 19/07417-0)

BICIGO DELINOCENTE, MAICON LUIS; LUIZ, MARIANE MARQUES; DE OLIVEIRA, DAYANE CAPRA; DE SOUZA, ALINE FERNANDA; RAMIREZ, PAULA CAMILA; MAXIMO, ROBERTA DE OLIVEIRA; SOARES, NATALIA COCHAR; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia?. CALCIFIED TISSUE INTERNATIONAL, v. 111, n. 6, p. 9-pg., 2022-09-15. (18/13917-3, 19/07417-0)

RAMIREZ, PAULA CAMILA; DE OLIVEIRA, DAYANE CAPRA; MAXIMO, ROBERTA DE OLIVEIRA; DE SOUZA, ALINE FERNANDA; LUIZ, MARIANE MARQUES; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Is dynapenic abdominal obesity a risk factor for cardiovascular mortality? A competing risk analysis. AGE AND AGEING, v. 52, n. 1, p. 9-pg., 2023-01-08. (18/13917-3)

LUIZ, MARIANE MARQUES; SCHNEIDER, IONE JAYCE CEOLA; KURIKI, HELOYSE ULIAM; FATTORI, ANDRE; CORREA, VANESSA PEREIRA; STEPTOE, ANDREW; ALEXANDRE, TIAGO DA SILVA; DE OLIVEIRA, CESAR. The combined effect of anemia and dynapenia on mortality risk in older adults: 10-Year evidence from the ELSA cohort study. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 102, p. 7-pg., 2022-09-01. (18/13917-3)

MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, DAYANE CAPRA; RAMIREZ, PAULA CAMILA; LUIZ, MARIANE MARQUES; DE SOUZA, ALINE FERNANDA; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Combination of dynapenia and abdominal obesity affects long-term physical performance trajectories in older adults: sex differences. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 115, n. 5, p. 10-pg., 2022-01-31. (17/26377-4, 18/13917-3)

NEBULONI, CLARICE CAVALERO; MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 75, n. 6, p. 1191-1197, JUN 2020. (18/13917-3)

DE SOUZA, ALINE FERNANDA; MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, DAYANE CAPRA; RAMIREZ, PAULA CAMILA; LUIZ, MARIANE MARQUES; BICIGO DELINOCENTE, MAICON LUIS; FERREIRA SANTOS, JAIR LICIO; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Gender differences in the association between adverse events in childhood or adolescence and the risk of premature mortality. SCIENTIFIC REPORTS, v. 12, n. 1, p. 11-pg., 2022-11-09. (18/13917-3)

DE OLIVEIRA, DAYANE CAPRA; MAXIMO, ROBERTA DE OLIVEIRA; RAMIREZ, PAULA CAMILA; DE SOUZA, ALINE FERNANDA; LUIZ, MARIANE MARQUES; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Does the incidence of frailty differ between men and women over time?. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 106, p. 8-pg., 2023-03-01. (18/13917-3)

LUIZ, MARIANE M.; MAXIMO, ROBERTA; OLIVEIRA, DAYANE C.; RAMIREZ, PAULA C.; DE SOUZA, ALINE F.; DELINOCENTE, MAICON L. B.; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO. Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults > 50 Years of Age. Journal of Nutrition, v. 150, n. 11, p. 2977-2984, NOV 2020. (18/13917-3)

BICIGO DELINOCENTE, MAICON LUIS; TREVISAN DE CARVALHO, DANILO HENRIQUE; MAXIMO, ROBERTA DE OLIVEIRA; NISIHARA CHAGAS, MARCOS HORTES; FERREIRA SANTOS, JAIR LICIO; DE OLIVEIRA DUARTE, YEDA APARECIDA; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Accuracy of different handgrip values to identify mobility limitation in older adults. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 94, MAY-JUN 2021. (18/13917-3, 09/53778-3)

DE OLIVEIRA, DAYANE CAPRA; MAXIMO, ROBERTA DE OLIVEIRA; RAMIREZ, PAULA CAMILA; DE SOUZA, ALINE FERNANDA; LUIZ, MARIANE MARQUES; BICIGO DELINOCENTE, MAICON LUIS; NISIHARA CHAGAS, MARCOS HORTES; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Is slowness a better discriminator of disability than frailty in older adults?. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, SEP 2021. (18/13917-3)

LUIZ, MARIANE MARQUES; MAXIMO, ROBERTA DE OLIVEIRA; DE OLIVEIRA, DAYANE CAPRA; RAMIREZ, PAULA CAMILA; DE SOUZA, ALINE FERNANDA; BICIGO DELINOCENTE, MAICON LUIS; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Sex Differences in Vitamin D Status as a Risk Factor for Incidence of Disability in Instrumental Activities of Daily Living: Evidence from the ELSA Cohort Study. NUTRIENTS, v. 14, n. 10, p. 11-pg., 2022-05-01. (18/13917-3)

SOUZA, ISABELLA LETICIA DE PADUA CRUZ E; DE OLIVEIRA, DAYANE CAPRA; SOUZA, THALES BATISTA; RAMIREZ, PAULA CAMILA; SOARES, NATALIA COCHAR; LUIZ, MARIANE MARQUES; DELINOCENTE, MAICON LUIS BICIGO; STEPTOE, ANDREW; DE OLIVEIRA, CESAR; ALEXANDRE, TIAGO DA SILVA. Dynapenia and sarcopenia identify walking speed decline in women but not in men. ARCHIVES OF GERONTOLOGY AND GERIATRICS, v. 126, p. 10-pg., 2024-06-30. (21/11505-2, 18/13917-3)

COCHAR-SOARES, NATALIA; DE CARVALHO, DANILO H. T.; DE ANDRADE, FABIOLA B.; CASTRO-COSTA, ERICO; DE OLIVEIRA, CESAR; LIMA-COSTA, MARIA F.; ALEXANDRE, TIAGO DA S.. Does undiagnosed diabetes mitigate the association between diabetes and cognitive impairment? Findings from theELSI-Brazilstudy. JOURNAL OF DIABETES, v. 12, n. 11, p. 10-pg., 2020-07-22. (18/13917-3, 17/22818-6)

TOFANI, PATRICIA SILVA; MAXIMO, ROBERTA DE OLIVEIRA; COCHAR-SOARES, NATALIA; RAMIREZ, PAULA CAMILA; LUIZ, MARIANE MARQUES; LIMA, SARA SOUZA; DA SILVA, THAIS BARROS PEREIRA; DE SOUZA, THALES BATISTA; SILVEIRA, LETICIA COELHO; GUANDALINI, VALDETE REGINA; et al. Does the coexistence of pain and depressive symptoms accelerate cognitive decline?. AGING & MENTAL HEALTH, v. N/A, p. 9-pg., 2024-08-13. (18/13917-3)

SOUZA, I.; OLIVEIRA, D. C.; SOUZA, T. B.; RAMIREZ, P. C.; SOARES, N. C.; LUIZ, M. M.; DELINOCENTE, M. L. B.; STEPTOE, A.; OLIVEIRA, C.; ALEXANDRE, T. S.. DYNAPENIA, LOW MUSCLE MASS OR SARCOPENIA: WHICH BEST PREDICTS MOBILITY DECLINE IN OLDER WOMEN WITH NORMAL GAIT SPEED?. AGING CLINICAL AND EXPERIMENTAL RESEARCH, v. 35, p. 1-pg., 2023-07-01. (21/11505-2, 18/13917-3)

ROBERTA DE OLIVEIRA MÁXIMO; INGRID CRISTINA LOPES; ALLAN GUSTAVO BRIGOLA; BRUNA MORETTI LUCHESI; ALINE CRISTINA MARTINS GRATÃO; KEIKA INOUYE; SOFIA CRISTINA IOST PAVARINI; TIAGO DA SILVA ALEXANDRE. Pre-frailty, frailty and associated factors in older caregivers of older adults. Revista de Saúde Pública, v. 54, 2020-01-31. (17/26377-4, 18/13917-3)