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Glaucoma as a model of temporal information disruption: impact on the metabolism

Grant number: 17/26651-9
Support Opportunities:Research Grants - Young Investigators Grants
Duration: September 01, 2019 - August 31, 2024
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Maria Nathália de Carvalho Magalhães Moraes Figueira Borges
Grantee:Maria Nathália de Carvalho Magalhães Moraes Figueira Borges
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
Associated researchers:Ana Maria de Lauro Castrucci ; Ignacio Provencio ; José Cipolla Neto ; Verena Voget
Associated grant(s):22/15729-5 - Multi-user Equipment approved in grant 2017/26651-9: real time PCR QuantStudio 5, Applied Biosystems, AP.EMU
Associated scholarship(s):23/08461-9 - Contribution of GPNMB protein on temporal control and hepatic glucose metabolism in mice subjected to a hyperlipidic diet, BP.MS
22/07969-6 - Characterization of the hypothalamic-pituitary-adrenal axis in glaucomatous mice, BP.MS
+ associated scholarships 22/01930-0 - Evaluation of glaucoma induced secondary changes on the biological clock and liver metabolism, BP.IC
20/13615-7 - Evaluation of retinal physiology throughout the development of glaucoma: study of changes in biological rhythm, synthesis of melatonin and opsins, BP.IC
20/04012-7 - Glaucoma as a model of chronodisruption: impact on the metabolism, BP.IC
19/19005-9 - Glaucoma as a model of chronodisruption: impact on the metabolism, BP.JP - associated scholarships


The retina, through melanopsin-positive ganglion cells, constitutes the main input of light information to entrain the mammalian central oscillator, the suprachiasmatic nuclei (SCN). The clock molecular mechanism in SCN is responsible for the generation of rhythmic function, which is transmitted to other organs, allowing the whole organism to align the internal time in harmony with the external one. The loss of internal temporal relationship among different organs / functions can generate a disruption of the phase synchrony between different organ clocks, a phenomenon known as chronodisruption, which is linked to changes in physiology, leading to a pathological condition. In fact, chronic exposure to low light intensity at night has been related to metabolic and hormonal disfunctions. On the other hand, would individuals with a compromised light transduction to the central clock develop changes in physiological parameters? To answer this question, animals that spontaneously develop glaucoma become an ideal model, since they exhibit progressive degeneration of the retinal ganglion layer. What are the short and long-term consequences of the lack of light exposure? Could secondary pathologies result from glaucoma? The present study aims: to evaluate, during the development and progression of glaucoma, the transcripts in organs related to metabolism through next-generation sequence; to verify the existence of a possible trans-synaptic degeneration between retina and SCN; to establish the cause-and-effect relationship between dysregulation of the clock molecular machinery and the development of pathologies in peripheral tissues related to metabolism; to verify if the metabolism of glaucomatous animals could be affected by the activation of the skin photo/thermo-reception system. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORAES, MARIA NATHALIA; DE ASSIS, LEONARDO VINICIUS MONTEIRO; PROVENCIO, IGNACIO; CASTRUCCI, ANA MARIA DE LAURO. Opsins outside the eye and the skin: a more complex scenario than originally thought for a classical light sensor. Cell and Tissue Research, v. 385, n. 3, . (17/26651-9, 17/24615-5, 18/14728-0)
SUA-CESPEDES, CRISTHIAN D.; DAVID, DANIELA DANTAS; SOUTO-NETO, JOSE A.; LIMA, OTONIEL GONCALVES; MORAES, MARIA NATHALIA; DE ASSIS, LEONARDO V. MONTEIRO; CASTRUCCI, ANA MARIA DE LAURO. Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio. FRONTIERS IN PHYSIOLOGY, v. 12, . (18/23043-0, 18/16511-8, 17/26651-9, 18/14728-0, 17/24615-5, 18/23915-8)
MONTEIRO DE ASSIS, LEONARDO VINICIUS; MENDES, DAVI; SILVA, MATHEUS MOLINA; KINKER, GABRIELA SARTI; PEREIRA-LIMA, ISABELLA; MORAES, MARIA NATHALIA; MARTINS MENCK, CARLOS FREDERICO; DE LAURO CASTRUCCI, ANA MARIA. Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1867, n. 10, . (14/27287-0, 19/19435-3, 13/24337-4, 17/24615-5, 12/50214-4, 18/16511-8, 17/26651-9, 17/18781-0, 18/14728-0, 17/24217-0)
FORNI, MARIA FERNANDA; ALBERTO DOMINGUEZ-AMOROCH, OMAR; MONTEIRO DE ASSIS, LEONARDO VINICIUS; KINKER, GABRIELA SARTI; MORAES, MARIA NATHALIA; DE LAURO CASTRUCCI, ANA MARIA; SARAIVA CAMARA, NIELS OLSEN. An Immunometabolic Shift Modulates Cytotoxic Lymphocyte Activation During Melanoma Progression in TRPA1 Channel Null Mice. FRONTIERS IN ONCOLOGY, v. 11, . (18/16511-8, 18/14728-0, 17/16711-4, 17/26651-9, 17/24615-5)
DE ASSIS, LEONARDO VINICIUS MONTEIRO; MORAES, MARIA NATHALIA; MENDES, DAVI; SILVA, MATHEUS MOLINA; MENCK, CARLOS FREDERICO MARTINS; CASTRUCCI, ANA MARIA DE LAURO. Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes. CURRENT ISSUES IN MOLECULAR BIOLOGY, v. 43, n. 3, p. 1436-1450, . (18/16511-8, 17/24615-5, 17/26651-9, 17/18781-0, 19/19435-3, 18/14728-0, 17/24217-0)
MONTEIRO DE ASSIS, LEONARDO VINICIUS; LACERDA, JOSE THALLES; MORAES, MARIA NATHALIA; DOMINGUEZ-AMOROCHO, OMAR ALBERTO; KINKER, GABRIELA SARTI; MENDES, DAVI; SILVA, MATHEUS MOLINA; MARTINS MENCK, CARLOS FREDERICO; SARAIVA CAMARA, NIELS OLSEN; DE LAURO CASTRUCCI, ANA MARIA. Melanopsin (Opn4) is an oncogene in cutaneous melanoma. COMMUNICATIONS BIOLOGY, v. 5, n. 1, p. 15-pg., . (19/19435-3, 19/25129-2, 17/24217-0, 17/26651-9, 18/16511-8, 12/50214-4, 18/14728-0, 17/24615-5, 17/18781-0, 20/04524-8, 13/24337-4, 17/16711-4)
LACERDA, JOSE THALLES; GOMES, PATRICIA R. L.; ZANETTI, GIOVANNA; MEZZALIRA, NATHANA; LIMA, OTONIEL G.; DE ASSIS, LEONARDO V. M.; GULER, ALI; CASTRUCCI, ANA MARIA; MORAES, MARIA NATHALIA. Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 13, p. 24-pg., . (17/24615-5, 21/01659-2, 14/16412-9, 20/04524-8, 18/23915-8, 18/16511-8, 13/02131-5, 12/50214-4, 18/14728-0, 17/26651-9, 21/09923-0)
SUA-CESPEDES, CRISTHIAN; LACERDA, JOSE THALLES; ZANETTI, GIOVANNA; DAVID, DANIELA DANTAS; MORAES, MARIA NATHALIA; DE ASSIS, LEONARDO V. M.; CASTRUCCI, ANA MARIA L.. Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 242, p. 15-pg., . (16/00696-3, 13/07937-8, 19/19005-9, 21/01659-2, 17/26651-9, 18/23043-0, 18/16511-8, 12/50214-4, 12/12663-1, 18/14728-0, 17/24615-5, 20/04524-8, 14/16412-9)
GALVAO VALDIVIA, LUIS FELIPE; CASTRO, ERIQUE; DOS SANTOS EICHLER, ROSANGELA APARECIDA; MORENO, MAYARA FRANZOI; DE SOUSA, ERICA; RODRIGUES JARDIM, GIOVANNA FREITAS; PEIXOTO, ALBERT SOUZA; MORAES, MARIA NATHALIA; DE LAURO CASTRUCCI, ANA MARIA; NEDERGAARD, JAN; et al. Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 324, n. 4, p. 16-pg., . (17/26651-9, 21/02953-1, 19/01763-4, 20/04159-8, 18/14728-0, 21/03717-0, 17/24615-5, 19/25943-1)

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