Computational and systems neuroscience

• Grant number: 18/20277-0
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2019
• End date: March 31, 2021
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Agreement: FACEPE
• Principal Investigator: Antonio Carlos Roque da Silva Filho
• Grantee: Antonio Carlos Roque da Silva Filho
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Bóris Marin ; Marcelo Bussotti Reyes ; Nivaldo Antonio Portela de Vasconcelos ; Osame Kinouchi Filho ; Pedro Valadão Carelli

Abstract

This project aims to support and consolidate the collaborative research between the Physics Department of theUniversidade Federal de Pernambuco (DF-UFPE, Recife), the Physics Department of FFCLRP of the Universidadede São Paulo (USP, Ribeirão Preto), and the Center for Mathematics, Computation and Cognition from Universidade Federal do ABC (UFABC, São Bernardo do Campo, SP). The research we have been developping has four main topics: i) Criticality in the brain ii) Cortical dynamics iii) Anticipated synchronization and iv) Computational Psyquiatry. In the first three topics we use computational models, data analysis and experiments based on extracellular recordings with multielectrode arrays, combining efforts in both theory and experiments. In the fourth topic, we bring tecniques from statistical physics and complex networks to the speech analysis of psycotic patients. We show that it is possible to help the diagnosis of psychiatric disorders with the development of quantitative indicators based only on the speech. This proposal aims to reinforce the necessary infrastructure for this kind of research, including resourses for boosting the storage of computational cluster and massive electrophysiological data, consumables for laboratory, services (imports and publication costs), among others. A crucial part of the funding is to promote research interchanges between researchers and students of the two states. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, VINICIUS; PENA, RODRIGO F. O.; SHIMOURA, RENAN O.; KAMIJI, NILTON L.; CEBALLOS, CESAR C.; BORGES, FERNANDO S.; HIGA, GUILHERME S. V.; DE PASQUALE, ROBERTO; ROQUE, ANTONIO C.. Modeling and characterizing stochastic neurons based on in vitro voltage-dependent spike probability functions. European Physical Journal-Special Topics, JUN 2021. (17/07688-9, 19/14962-5, 15/50122-0, 18/20277-0, 17/18977-1, 11/50151-0, 16/03855-5, 13/25667-8, 13/07699-0)

KINOUCHI, OSAME; PAZZINI, RENATA; COPELLI, MAURO. Mechanisms of Self-Organized Quasicriticality in Neuronal Network Models. FRONTIERS IN PHYSICS, v. 8, DEC 23 2020. (19/12746-3, 13/07699-0, 18/20277-0)

GRIFFITHS, VICTORIA A.; VALERA, ANTOINE M.; LAU, JOANNA Y. N.; ROS, HANA; YOUNTS, THOMAS J.; MARIN, BORIS; BARAGLI, CHIARA; COYLE, DICCON; EVANS, GEOFFREY J.; KONSTANTINOU, GEORGE; et al. Real-time 3D movement correction for two-photon imaging in behaving animals. NATURE METHODS, v. 17, n. 7, JUN 2020. (18/20277-0)

PENA, RODRIGO F. O.; LIMA, VINICIUS; O. SHIMOURA, RENAN; PAULO NOVATO, JOAO; ROQUE, ANTONIO C.. Optimal Interplay between Synaptic Strengths and Network Structure Enhances Activity Fluctuations and Information Propagation in Hierarchical Modular Networks. BRAIN SCIENCES, v. 10, n. 4, APR 2020. (13/07699-0, 15/50122-0, 17/07688-9, 18/20277-0, 17/05874-0, 13/25667-8)

SHIMOURA, RENAN OLIVEIRA; PENA, RODRIGO F. O.; LIMA, VINICIUS; KAMIJI, NILTON L.; GIRARDI-SCHAPPO, MAURICIO; ROQUE, ANTONIO C.. Building a model of the brain: from detailed connectivity maps to network organization. European Physical Journal-Special Topics, v. 230, n. 14-15, p. 2887-2909, OCT 2021. (13/25667-8, 17/07688-9, 18/09150-9, 18/20277-0, 16/03855-5, 13/07699-0, 15/50122-0)

TUNES, GABRIELA C.; DE OLIVEIRA, ELIEZYER FERMINO; VIEIRA, ESTEVAO U. P.; CAETANO, MARCELO S.; CRAVO, ANDRE M.; BUSSOTTI REYES, MARCELO. Time encoding migrates from prefrontal cortex to dorsal striatum during learning of a self-timed response duration task. eLIFE, v. 11, p. 19-pg., 2022-09-28. (16/05473-2, 14/50909-8, 18/20277-0, 17/03729-2, 17/25161-8)

AGUIAR, LEANDRO A. A.; DE VASCONCELOS, NIVALDO A. P.; TUNES, GABRIELA CHIUFFA; FONTENELE, ANTONIO J.; NOGUEIRA, ROMILDO DE ALBUQUERQUE; REYES, MARCELO BUSSOTTI; CARELLI, PEDRO, V. Low-cost open hardware system for behavioural experiments simultaneously with electrophysiological recordings. HARDWAREX, v. 8, p. 11-pg., 2020-10-01. (18/20277-0, 16/18914-7)

SHIMOURA, RENAN OLIVEIRA; PENA, RODRIGO F. O.; LIMA, VINICIUS; KAMIJI, NILTON L.; GIRARDI-SCHAPPO, MAURICIO; ROQUE, ANTONIO C.. Building a model of the brain: from detailed connectivity maps to network organization. European Physical Journal-Special Topics, JUN 2021. (17/07688-9, 18/09150-9, 15/50122-0, 18/20277-0, 16/03855-5, 13/25667-8, 13/07699-0)

ROMARO, CECILIA; NAJMAN, FERNANDO ARAUJO; LYTTON, WILLIAM W.; ROQUE, ANTONIO C.; DURA-BERNAL, SALVADOR. LNetPyNE Implementation and Scaling of the Potjans-Diesmann Cortical Microcircuit Model. NEURAL COMPUTATION, v. 33, n. 7, p. 1993-2032, JUL 2021. (15/50122-0, 18/20277-0, 13/07699-0)

LIMA, VINICIUS; PENA, RODRIGO F. O.; SHIMOURA, RENAN O.; KAMIJI, NILTON L.; CEBALLOS, CESAR C.; BORGES, FERNANDO S.; HIGA, GUILHERME S. V.; DE PASQUALE, ROBERTO; ROQUE, ANTONIO C.. Modeling and characterizing stochastic neurons based on in vitro voltage-dependent spike probability functions. European Physical Journal-Special Topics, v. 230, n. 14-15, p. 2963-2972, OCT 2021. (17/18977-1, 11/50151-0, 13/25667-8, 17/07688-9, 18/20277-0, 16/03855-5, 19/14962-5, 13/07699-0, 15/50122-0)

GIRARDI-SCHAPPO, MAURICIO; GALERA, EMILIO F.; CARVALHO, TAWAN T. A.; BROCHINI, LUDMILA; KAMIJI, NILTON L.; ROQUE, ANTONIO C.; KINOUCHI, OSAME. A unified theory of E/I synaptic balance, quasicritical neuronal avalanches and asynchronous irregular spiking. JOURNAL OF PHYSICS-COMPLEXITY, v. 2, n. 4, DEC 2021. (19/12746-3, 18/09150-9, 18/20277-0, 16/24676-1, 13/07699-0, 15/50122-0, 16/03855-5)