INCT 2014 - of obesity and diabetes

• Grant number: 14/50907-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: October 01, 2020
• End date: September 30, 2026
• Field of knowledge: Health Sciences - Medicine
• Agreement: CNPq - INCTs
• Principal Investigator: Mario Jose Abdalla Saad
• Grantee: Mario Jose Abdalla Saad
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Principal investigators: Alexandre Gabarra de Oliveira ; Patrícia de Oliveira Prada
• Associated research grant(s): 24/01622-0 - Study of the pathophysiological mechanisms involved in Insulin Resistance (IR), Type 2 Diabetes Mellitus (DM2) and its associated diseases, such as Atherosclerosis, AP.R
• Associated scholarship(s): 24/22614-5 - Central and peripheral actions of GLP-1, GIP, and glucagon in the subclinical inflammatory process: immunometabolic contribution, BP.PD; 24/08838-8 - Synthesis of chitosan nanoparticles for encapsulation of antidiabetic drugs, BP.IC

Scientific publications

(11)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MONTENEGRO, RENAN MAGALHAES, JR.; MELO PONTE, CLARISSE MOURAO; COSTA GURGEL CASTELO, MARIA HELANE; DE OLIVEIRA SILVEIRA, ALESSANDRO CONRADO; FERNANDES, VIRGINIA OLIVEIRA; D'ALVA, CATARINA BRASIL; VALTER OLIVEIRA, LUIZ FELIPE; HRISTOV, ANGELICA DOMINGUES; BANDEIRA, SILVIANE PRACIANO; DA CRUZ PAIVA, GRAYCE ELLEN; et al. Reduced gut microbiota diversity in patients with congenital generalized lipodystrophy. DIABETOLOGY & METABOLIC SYNDROME, v. 14, n. 1, p. 12-pg., 2022-09-24. (14/50907-5)

BERBERT, L.; SANTOS, A.; MAGRO, D. O.; GUADAGNINI, D.; ASSALIN, H. B.; LOURENCO, L. H.; MARTINEZ, C. A. R.; SAAD, M. J. A.; COY, C. S. R.. Metagenomics analysis reveals universal signatures of the intestinal microbiota in colorectal cancer, regardless of regional differences. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, p. 9-pg., 2022-01-01. (14/50907-5)

ASSALIN, HELOISA B.; GABRIEL DE ALMEIDA, KELLY CRISTIANE; GUADAGNINI, DIOZE; SANTOS, ANDREY; TEIXEIRA, CAIO J.; BORDIN, SILVANA; ROCHA, GUILHERME Z.; SAAD, MARIO J. A.. Proton Pump Inhibitor Pantoprazole Modulates Intestinal Microbiota and Induces TLR4 Signaling and Fibrosis in Mouse Liver. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 22, p. 18-pg., 2022-11-01. (19/03196-0, 14/50907-5, 20/06397-3)

TOBAR, NATALIA; ROCHA, GUILHERME Z.; SANTOS, ANDREY; GUADAGNINI, DIOZE; ASSALIN, HELOISA B.; CAMARGO, JULIANA A.; GONCALVES, ANY E. S. S.; PALLIS, FLAVIA R.; OLIVEIRA, ALEXANDRE G.; ROCCO, SILVANA A.; et al. Metformin acts in the gut and induces gut-liver crosstalk. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 120, n. 4, p. 11-pg., 2023-01-24. (14/50907-5)

ZANOTTO, TAMIRES M.; GONCALVES, ANY ELISA DE SOUZA SCHMIDT; SAAD, MARIO J. A.. Pulmonary hypertension and insulin resistance: a mechanistic overview. FRONTIERS IN ENDOCRINOLOGY, v. 14, p. 10-pg., 2024-01-04. (14/50907-5)

DA SILVEIRA JR, VAGNER FRANCO; SILVA, JULIANY LINO GOMES; LIMA, MARIA HELENA MELO; SAAD, MARIO JOSE ABDALLA. Effects of Topical Insulin on Second-Degree Burn Wound Healing: Brief Report. WOUND MANAGEMENT & PREVENTION, v. 70, n. 2, p. 7-pg., 2024-06-01. (14/50907-5)

SAAD, MARIO J. A.; SANTOS, ANDREY. The Microbiota and Evolution of Obesity. ENDOCRINE REVIEWS, v. N/A, p. 17-pg., 2024-12-24. (14/50907-5)

DANIELA O MAGRO; CARINA ROSSONI; ROGERIO SAAD-HOSSNE; ANDREY SANTOS. . Arq. Gastroenterol., v. 60, n. 1, p. 132-136, 2023-05-12. (14/50907-5)

P.P. APOLINÁRIO; F.C. ZANCHETTA; J.S.C. BREDER; G. ADAMS; S.R. CONSONNI; R. GILLIS; M.J.A. SAAD; M.H.M. LIMA. Anti-inflammatory, procollagen, and wound repair properties of topical insulin gel. Brazilian Journal of Medical and Biological Research, v. 56, 2023-05-15. (14/50907-5)

NORBERTO, SONIA; ASSALIN, HELOISA BALAN; GUADAGNINI, DIOZE; TOBAR, NATALIA; BOER, PATRICIA ALINE; KANG, MIN-CHEOL; SAAD, MARIO JOSE ABDALLA; KIM, YOUNG-BUM; PRADA, PATRICIA OLIVEIRA. CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion. FRONTIERS IN ENDOCRINOLOGY, v. 14, p. 16-pg., 2023-08-10. (14/50907-5, 18/20087-7, 18/18341-2)

DE MACEDO, JULIANE COLOMBO CARRER; GUADAGNINI, DIOZE; ASSALIN, HELOISA B.; OLIVEIRA, EMILIA SOUSA; MAGRO, DANIELA O.; ALBORGHETTI, MARCOS R.; SFORCA, MAURICIO L.; ROCCO, SILVANA A.; SANTOS, ANDREY; SAAD, MARIO J. A.. Vildagliptin modulates the microbiota and induces an immunometabolic profile compatible with neuroprotection in type 2 diabetes. SCIENTIFIC REPORTS, v. 15, n. 1, p. 11-pg., 2025-07-31. (14/50907-5)