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Development of a low cost and noninvasive rapid test for the diagnosis of bladder cancer

Grant number: 20/02015-9
Support Opportunities:Research Grants - Innovative Research in Small Business - PIPE
Duration: March 01, 2021 - June 30, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Juliane Cristina Borba
Grantee:Juliane Cristina Borba
Host Company:Solve Biotechnology Ltda. - ME
CNAE: Pesquisa e desenvolvimento experimental em ciências físicas e naturais
City: São Carlos
Associated researchers:Regiane de Fátima Travensolo
Associated research grant:16/21759-3 - Development of a fast, low cost and non invasive test for bladder cancer diagnostic, AP.PIPE
Associated scholarship(s):21/01616-1 - Development of a low cost and noninvasive rapid test for the diagnosis of Bladder Cancer, BP.PIPE

Abstract

Bladder cancer is a urogenital neoplasia that affects men and women, and only 9,670 new cases per year are diagnosed in Brazil alone. Cystoscopy transurethral is the standard approach in the diagnosis and monitoring of bladder cancer. However, such a procedure is extremely invasive and painful in addition to having a high cost and not guaranteeing all the results of expected success. In addition, in the early stages, the symptoms are not specific to the disease, being similar to other urinary disorders, which hinders the correct diagnosis of the disease and, therefore, in many cases cancer is only discovered when it is already in an advanced stage. Thus, the search for effective diagnostic tests that can assist in the early diagnosis and / or progression of bladder cancer, as well as reducing the need for invasive tests to monitor the disease. In this sense, biological fluids such as urine have a prominent role due mainly to their non-invasive character. This project proposes the development of a quick, simple, low-cost and non-invasive diagnostic kit, aiming to assist the existing conventional methods. With the optimization of a production methodology of colored and functionalized polystyrene nanoparticles, an agglutination test will be carried out to detect different bladder cancer-related biomarkers which are expelled in the urine. (AU)

Articles published in Pesquisa para Inovação FAPESP about research grant:
Brazilian startup develops rapid test to diagnose bladder cancer 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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