Theranostic nanodevices with dosimetric properties for medical physics applications

• Grant number: 21/00786-0
• Support Opportunities: Regular Research Grants
• Duration: October 01, 2021 - March 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Éder José Guidelli
• Grantee: Éder José Guidelli
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Nanoscience and nanotechnology are areas of great and still increasing interest in the last years. Hybrid nanoparticles are now attracting more and more investigation interest since they present peculiar optical features such as enhanced photoluminescence quantum yields. In Medical Physics, these nanoparticles are essential for the development of advanced radiation detectors, besides applications on new cancer therapies such as plasmonic photothermal therapy and x-ray activated photodynamic therapy. The physical properties of these nanodevices can be adjusted according to the composition, structure, shape and size of the nanoparticles. Therefore, the challenge is to engineer the nanoparticle with specific properties for each application. The main goal of this proposal is the development of new hybrid nanoparticles, to perform structural and morphological characterization as well as surface modification and functionalization, in order to investigate their optical, luminescent, and dosimetric properties. These nanoparticles will be applied for ionizing radiation detection as well as in the development of new cancer therapeutics, thereby contributing to the advancement of the medical physics research field. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, I. N.; ISIKAWA, M. M.; NUNES, L. H. S.; MICHELETTO, M. C.; GUIDELLI, E. J.. Magnetic nanoparticles covered with polycyclic aromatic hydrocarbons as singlet oxygen carriers for combining photodynamic therapy and magnetic hyperthermia. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 444, p. 9-pg., 2023-10-01. (21/00786-0)