Sensing podocytes: connecting extra and intracellular worlds to orchestrate renal fate

• Grant number: 22/03740-4
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2022
• End date: July 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: Monash University
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Niels Olsen Saraiva Câmara
• Principal researcher abroad: John Frederick Bertram
• Institution abroad: Monash University, Australia
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Luise McEwen ; Maria Oliveira de Souza ; Orestes Foresto Neto ; Vinicius de Andrade Oliveira
• Associated research grant: 21/06748-3 - The role of gut HIF-1 signaling in kidney-gut crosstalk in kidney IRI, AP.R
• Associated research grant(s): 23/00686-1 - Interaction between proximal tubular cells and podocytes: peroxisome as interaction mediator, AP.R

Abstract

Chronic kidney diseases (CKD), mainly Glomerulopathies (GPs), are major health issues worldwide. GPs are difficult to manage due to variable responses to treatment and chances of reappearance after transplantation. Podocytes are the central cell in numerous GPs and CKD, playing crucial roles in maintaining renal physiology. We hypothesize that podocytes are renal-sensing cells that connect the extracellular world with intracellular organelles and signaling pathways, determining cell function and survival in GP and CKD, ultimately influencing renal functional fate. Podocyte number and morphology and new functions addressed in this proposal dictate survival and fitness of kidneys when facing stresses and injuries. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FORESTO-NETO, ORESTES; MENEZES-SILVA, LUISA; LEITE, JEFFERSON ANTONIO; ANDRADE-SILVA, MAGAIVER; CAMARA, NIELS OLSEN SARAIVA. Immunology of Kidney Disease. ANNUAL REVIEW OF IMMUNOLOGY, v. 42, p. 27-pg., 2024-01-01. (22/03740-4, 17/05264-7, 21/06748-3, 19/02893-9, 21/03192-4, 22/13289-8, 20/04592-3)

FORESTO-NETO, ORESTES; DA SILVA, ANA RUTH PAOLINETTI ALVES; CIPELLI, MARCELLA; SANTANA-NOVELLI, FERNANDA PAULA RONCON; CAMARA, NIELS OLSEN SARAIVA. The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism. KIDNEY RESEARCH AND CLINICAL PRACTICE, v. 42, n. 5, p. 18-pg., 2023-09-01. (22/03740-4, 17/05264-7, 21/06748-3, 19/02893-9, 22/01226-1)