Development of multifunctional photoprotective formulations for protection and treatment of skin and hair against the effects of exposome

• Grant number: 22/00897-0
• Support Opportunities: Regular Research Grants
• Duration: September 01, 2022 - August 31, 2024
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Patrícia Maria Berardo Gonçalves Maia Campos
• Grantee: Patrícia Maria Berardo Gonçalves Maia Campos
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 22/11725-5 - Development of multifunctional photoprotective formulations for protection and treatment of skin, BP.TT

Abstract

The human skin presents high susceptibility to damage resulting from exposure to different factors that make up the skin aging expossome. The interaction of these factors affects biological responses and on the therapeutic approach, itself focused on particular needs and expectations. Thus, it is imperative to protect the skin using multifunctional photoprotective formulations that go beyond protecting against solar radiation, i.e., that can act in the maintenance of cutaneous physiology, protection and repair of the skin barrier function and other damages related to the oxidative process, acting in the prevention of accelerated extrinsic aging. This way, the search for innovative active substances, antioxidants, peptides, natural or biotechnological extracts have been considered relevant complementary strategies for protection against free radical formation resulting from solar radiation and pollutants. In this context, the present project aims to develop multifunctional photoprotective formulations containing vitamins and extracts of natural origin with antioxidant, moisturizing and film-forming properties for the protection and treatment of skin and hair alterations resulting from the expossome, as well as to evaluate the efficacy of these formulations by means of a multidisciplinary approach based on in vitro methods and in vivo advanced biophysical and skin imaging techniques. (AU)