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Development of multifunctional photoprotective formulations for protection and treatment of skin and hair against the effects of exposome

Abstract

The human skin presents high susceptibility to damage resulting from exposure to different factors that make up the skin aging expossome. The interaction of these factors affects biological responses and on the therapeutic approach, itself focused on particular needs and expectations. Thus, it is imperative to protect the skin using multifunctional photoprotective formulations that go beyond protecting against solar radiation, i.e., that can act in the maintenance of cutaneous physiology, protection and repair of the skin barrier function and other damages related to the oxidative process, acting in the prevention of accelerated extrinsic aging. This way, the search for innovative active substances, antioxidants, peptides, natural or biotechnological extracts have been considered relevant complementary strategies for protection against free radical formation resulting from solar radiation and pollutants. In this context, the present project aims to develop multifunctional photoprotective formulations containing vitamins and extracts of natural origin with antioxidant, moisturizing and film-forming properties for the protection and treatment of skin and hair alterations resulting from the expossome, as well as to evaluate the efficacy of these formulations by means of a multidisciplinary approach based on in vitro methods and in vivo advanced biophysical and skin imaging techniques. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAKUDA, LETICIA; CAMPOS, PATRICIA MARIA BERARDO GONCALVES MAIA; ZANIN, RAFAELA BORDINI; FAVARO, LAURA NORONHA. Development of multifunctional sunscreens: Evaluation of physico-mechanical and film-forming properties. International Journal of Pharmaceutics, v. 635, p. 12-pg., . (21/11000-8, 22/00897-0)

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