Exploring the medicinal chemical space of aromatics with highly selective synthetic tools

• Grant number: 22/05327-7
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2022
• End date: November 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Giuliano Cesar Clososki
• Grantee: Giuliano Cesar Clososki
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant(s): 23/01384-9 - DEVELOPMENT OF A PLATFORM FOR SYNTHESIS AND ANALYTICAL CERTIFICATION OF PHARMACEUTICAL IMPURITIES, AP.R
• Associated scholarship(s): 24/19435-1 - Cross-coupling of Indolizines with (Pseudo)halides and Grignard Reagents by Earth-abundant Transition Metal Catalysis, BP.MS

Abstract

New techniques that combine artificial intelligence and robotics are increasingly impacting the Organic Synthesis and, consequently, the Medicinal Chemistry, especially with regard to the implementation of new synthetic approaches and process automation for the preparation of innovative libraries of drug candidates. These new technologies have created great opportunities for the use of methodologies little explored by Medicinal Chemists, especially for those that involve special reaction conditions, but that can be highly selective and compatible with reactors that operate in continuous flow, such as those based on organometallic reagents. In this project, we intend to develop methodologies for the preparation of functionalized aromatic and heterocyclic compounds that are highly chemoselective and regioselective and that can contribute to a better exploration of the medicinal chemical space in the drug discovery and development processes. In order to better understand, rationalize and plan regioselective functionalization reactions, computational chemistry tools will be used in the structural evaluation of synthetic targets. Furthermore, in order to combine synthetic developments with the synthesis of new potentially bioactive compounds, some structural planning strategies will be applied both for the identification of drug candidates and in the structural manipulation of prototypes, aiming at the optimization of biological activity. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARROIO, THAIS R.; BERTALLO, CAMILA R. S.; LEONELO, LAILA AP. D.; CAIRES, FRANCO J.; NAAL, ROSE M. Z. G.; CLOSOSKI, GIULIANO C.. Synthesis of novel π-extended 2,5-disubstituted indolizines and their absorption and fluorescence properties. Journal of Molecular Structure, v. 1315, p. 12-pg., 2024-06-17. (20/13962-9, 22/05327-7, 14/50867-3, 15/03007-1)

ARTUR DE LARA LIMA VAZ; JOÃO LUIS CALLEGARI LOPES; GIULIANO CESAR CLOSOSKI. Continuous flow Aza-Michael reaction for preparing the fast-acting synthetic opioid drug Remifentanil. Brazilian Journal of Pharmaceutical Sciences, v. 59, 2023-06-16. (16/12718-1, 22/05327-7)

MORAES, VITOR TASSARA; CAIRES, FRANCO JAZON; DA SILVA-NETO, PEDRO V.; MENDONCA, JACQUELINE NAKAU; FRAGA-SILVA, THAIS F. C.; FONTANEZI, BIANCA BUENO; MARCATO, PRISCYLA DANIELY; DEPERON BONATO, VANIA LUIZA; SORGI, CARLOS ARTERIO; BERALDO MORAES, LUIZ ALBERTO; et al. Naphthoquinone derivatives as potential immunomodulators: prospective for COVID-19 treatment. RSC ADVANCES, v. 14, n. 10, p. 10-pg., 2024-02-21. (22/05327-7, 22/16916-3, 14/50928-2, 21/13532-7)