| Grant number: | 23/02394-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2024 |
| End date: | January 31, 2026 |
| Field of knowledge: | Biological Sciences - Morphology - Histology |
| Principal Investigator: | Renata de Britto Mari |
| Grantee: | Renata de Britto Mari |
| Host Institution: | Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil |
| City of the host institution: | São Vicente |
| Associated researchers: | Caio Rodrigues Nobre ; Denis Moledo de Souza Abessa ; Marcos Antonio de Oliveira ; Paloma Kachel Gusso Choueri ; Rodrigo Brasil Choueri |
| Associated scholarship(s): | 25/02048-8 - SILENT DISRUPTORS: AGED PLASTIC MICROFIBERS AND IBUPROFEN IN THE REMODELING OF THE MICROBIOTA-GUT-BRAIN AND ENTEROHEPATIC AXES IN AQUATIC AND TERRESTRIAL MODELS, BP.PD |
Abstract
Microplastic pollution has been a growing concern in recent decades due to its impact on the environment. The adsorption capacity of the microplastic surface to various pollutants present in effluents, enhances the toxicity and dispersion capacity of these compounds in organisms at different levels of the trophic chain. Considering this problem, this work aims to evaluate the biochemical, cellular and histological alterations caused by plastic microfibers associated with the antibiotic amoxicillin in the gills, liver and intestine of the oyster biomodels Crassostrea brasiliana and two species of vertebrates: zebrafish Danio rerio and Wistar rats Rattus norvergicus. For this, the organisms will be exposed to treatments with nylon microfibers alone, amoxicillin alone and nylon microfibers fortified with amoxicillin, followed by a period of purification. After exposure, samples of gills, hepatopancreas, liver and intestine of organisms will be collected from each organism and changes in enzymes of the antioxidant system, lipid peroxidation (LPO), DNA damage (DNA strand-break) and histological damage will be evaluated. The data obtained will be statistically treated later, through the analysis of variance permutational (PERMANOVA) and analysis of principal components (PCA). It is expected that the results contribute to a better understanding of the mechanism of action and interaction between these contaminants and organisms of different trophic levels. (AU)
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