Aging-related neurodegenerative disorders: from the cell to the patient

• Grant number: 24/06017-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: July 01, 2025
• End date: June 30, 2030
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Luiz Roberto Giorgetti de Britto
• Grantee: Luiz Roberto Giorgetti de Britto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Elisa Mitiko Kawamoto Iwashe ; Orestes Vicente Forlenza ; Vagner Roberto Antunes
• Associated researchers: Alexander Henning Ulrich ; Andréa da Silva Torrão ; Artur Martins Novaes Coutinho ; Beatriz de Oliveira Monteiro ; Beatriz Gangale Muratori ; Caroline Cristiano Real Gregório ; Cristiano Raminelli ; Daniel Martins-de-Souza ; Daniele de Paula Faria ; Diego Luiz Rovaris ; Fernanda Crunfli ; Jacy Bezerra Parmera ; Leda Leme Talib ; Luciana Chagas Caperuto ; Monique Patricio Singulani ; Patricia Castelucci ; Roberto De Pasquale ; Suzete Maria Cerutti ; Tânia Araújo Viel

Abstract

The incidence of several diseases increases with aging, due to several changes that include genetic, epigenetic, organic and systemic factors, among others. This picture is very evident in the nervous system, a target of several pathological processes linked to aging. In the present proposal, we aim to study several aspects related mainly to the two most prevalent neurodegenerative diseases, namely Parkinson´s disease and Alzheimer´s disease. The focus of the research is the integrated construction of knowledge that produces a significant contribution mainly on the progression of those diseases and, at the same time, that enables the development of potential strategies to mitigate the neurodegenerative processes involved. In summary, we will develop an integrated and wide study, including cell culture models, animal models and neuroimaging, and reaching the patients, in the search for biomarkers that could reliably be used in the clinical practice. With this project, we sought to increment both the basic and translational research on those two neurodegenerative conditions in our area. The integrative approach, which is the main novelty of the proposal, may lead our groups to international standards of research in this field. (AU)