B-1 cells: origin, differentiation and participation in inflammation, scarring and rejection of implant

• Grant number: 04/08506-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2005
• End date: April 30, 2008
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Mario Mariano
• Grantee: Mario Mariano
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: Ieda Maria Longo Maugéri

Abstract

The present project aims to secure resources to support the continuity of the investigations into the physiopathology of the B-1 cells of the mouse. It was demonstrated in our laboratory that B-1 cells proliferate in adherent peritoneal cell cultures of the mouse transforming themselves into mononuclear phagocytes different from macrophages originating from monocytes. Furthermore, that these cells migrate from the peritoneal cavity of the mouse to the non-specific inflammatory focus. The limitations in knowledge about the physiopathology of the B-1 cells and the opportunity of obtaining it from these cells in culture provided the opportunity for the present project which aims to investigate the origin, differentiation and participation of these cells in the inflammation, scarring and rejection of grafts. It further aims to investigate the role of these cells in immunomodulation induced by P. acnes and their lipidic and proteic components. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, H. C.; POPI, A. F.; BACHI, A. L. L.; NONOGAKI, S.; LOPES, J. D.; MARIANO, M.. B-1 cells modulate the kinetics of wound-healing process in mice. Immunobiology, v. 215, n. 3, p. 215-222, MAR 2010. (04/08506-1)

LOPES, JOSE DANIEL; MARIANO, MARIO. B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties. Anais da Academia Brasileira de Ciências, v. 81, n. 3, p. 489-496, SEP 2009. (07/51501-9, 04/08506-1)

DE-GENNARO, LUIZ ANTONIO; POPI, ANA FLAVIA; DE ALMEIDA, SANDRO ROGRIO; LOPES, JOSE DANIEL; MARIANO, MARIO. B-1 cells modulate oral tolerance in mice. Immunology Letters, v. 124, n. 2, p. 63-69, JUN 4 2009. (04/08506-1)

POPI, A. F.; ZAMBONI, D. S.; MORTARA, R. A.; MARIANO, M.. Microbicidal property of B1 cell derived mononuclear phagocyte. Immunobiology, v. 214, n. 8, p. 664-673, AUG 2009. (04/08506-1)

POPI, ANA F.; MOTTA, FABIANA L. T.; MORTARA, RENATO A.; SCHENKMAN, SERGIO; LOPES, JOSE D.; MARIANO, MARIO. Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro. IMMUNOLOGY, v. 126, n. 1, p. 114-122, JAN 2009. (04/08506-1)