Energetic metabolism, intracellular homeostasis of CA2+ and mitochondrial oxidative stress in cell death

• Grant number: 06/59786-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2007
• End date: September 30, 2011
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Aníbal Eugênio Vercesi
• Grantee: Aníbal Eugênio Vercesi
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Helena Coutinho Franco de Oliveira ; Roger Frigério Castilho

Abstract

Alterations in the energetic metabolism associated with modifications in the offer of nutrients and oxygen, ionic transport, inhibition of components of the transport chain of electrons or increase in the production of reactive oxygen species can lead to cell death. This cell death caused by failures of the energetic metabolism is a possible cause of several disorders, including arteriosclerosis, cerebral stroke, methylmalonic acidemia and some neurodegenerative diseases. The compromising of the energetic metabolism also is an effective way of eliminating cancer cells or undesirable pathogenetic microorganisms. Our project aims to study specific mechanisms through which the energetic metabolism and the mitochondrial production of reactive oxygen species are regulated, and seeks to determine which molecular events associated with changes in the energetic metabolism, intracellular homeostasis of Ca2+ and production of species reactive to oxygen can lead to cell death. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUSANELLO, ESTELA N. B.; FIGUEIRA, TIAGO R.; MARQUES, ANA C.; NAVARRO, CLAUDIA D. C.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E.. Facilitation of Ca2+-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment. Cell Biology International, v. 42, n. 6, SI, p. 742-746, JUN 2018. (06/59786-0, 11/50400-0, 14/11261-2, 13/07607-8)

ROSSATO, FRANCO A.; ZECCHIN, KARINA G.; LA GUARDIA, PAOLO G.; ORTEGA, ROSE M.; ALBERICI, LUCIANE C.; COSTA, RUTE A. P.; CATHARINO, RODRIGO R.; GRANER, EDGARD; CASTILHO, ROGER F.; VERCESI, ANIBAL E.. Fatty Acid Synthase Inhibitors Induce Apoptosis in Non-Tumorigenic Melan-A Cells Associated with Inhibition of Mitochondrial Respiration. PLoS One, v. 9, n. 6, JUN 25 2014. (06/59786-0, 11/50400-0)

SALERNO, ALESSANDRO G.; PATRICIO, PATRICIA R.; BERTI, JAIRO A.; OLIVEIRA, HELENA C. F.. Cholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice. Biochemical Journal, v. 419, p. 6-pg., 2009-05-01. (06/59786-0)

BUSANELLO, ESTELA N. B.; FIGUEIRA, TIAGO R.; MARQUES, ANA C.; NAVARRO, CLAUDIA D. C.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E.. Facilitation of Ca2+-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment. Cell Biology International, v. 42, n. 6, p. 5-pg., 2018-06-01. (11/50400-0, 06/59786-0, 14/11261-2, 13/07607-8)

IRIGOIN, FLORENCIA; INADA, NATALIA M.; FERNANDES, MARIANA P.; PIACENZA, LUCIA; GADELHA, FERNANDA R.; VERCESI, ANIBAL E.; RADI, RAFAEL. Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi. Biochemical Journal, v. 418, n. 3, p. 595-604, MAR 15 2009. (06/59786-0)

SALERNO, ALESSANDRO G.; PATRICIO, PATRICIA R.; BERTI, JAIRO A.; OLIVEIRA, HELENA C. F.. Cholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice. Biochemical Journal, v. 419, n. 3, p. 629-634, MAY 1 2009. (06/59786-0)

MORI, MATEUS P.; COSTA, RUTE A. P.; SOLTYS, DANIELA T.; FREIRE, THIAGO DE S.; ROSSATO, FRANCO A.; AMIGO, IGNACIO; KOWALTOWSKI, ALICIA J.; VERCESI, ANBAL E.; DE SOUZA-PINTO, NADJA C.. Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress. SCIENTIFIC REPORTS, v. 7, MAR 13 2017. (12/11889-6, 08/57952-5, 10/51906-1, 11/50400-0, 08/57721-3, 06/59786-0, 13/07937-8)

VERCESI, ANIBAL E.; CASTILHO, ROGER F.; KOWALTOWSKI, ALICIA J.; DE OLIVEIRA, HELENA C. F.; DE SOUZA-PINTO, NADJA C.; FIGUEIRA, TIAGO R.; BUSANELLO, ESTELA N. B.. Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radical Biology and Medicine, v. 129, p. 1-24, DEC 2018. (17/17728-8, 11/50400-0, 06/59786-0, 14/11261-2, 13/07607-8)

ALBERICI, LUCIANE C.; PAIM, BRUNO A.; ZECCHIN, KARINA G.; MIRANDOLA, SANDRA R.; PESTANA, CEZAR R.; CASTILHO, ROGER F.; VERCESI, ANIBAL E.; OLIVEIRA, HELENA C. F.. Activation of the mitochondrial ATP-sensitive K+ channel reduces apoptosis of spleen mononuclear cells induced by hyperlipidemia. LIPIDS IN HEALTH AND DISEASE, v. 12, JUN 14 2013. (06/59786-0, 11/50400-0)

IRIGOIN, FLORENCIA; INADA, NATALIA M.; FERNANDES, MARIANA P.; PIACENZA, LUCIA; GADELHA, FERNANDA R.; VERCESI, ANIBAL E.; RADI, RAFAEL. Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi. Biochemical Journal, v. 418, p. 10-pg., 2009-03-15. (06/59786-0)