Head and neck cancer is one of the most frequent cancers in the world and squamous cell carcinoma is the most common variant of this kink of cancer. The therapeutic strategy to head and neck squamous cell carcinoma (HNSCC) is based on tumor site and TNM stage. However, in many cases, tumors showing the same clinical stage and treated by the same approach, have different recurrence profiles and risk to death. An improvement in the actual knowledge about the biologic behavior of HNSCC may conduct to a clearest delineation of the tumor potential of invasion and metastatization. So that, the current efforts are to develop laboratory methodologies to help in the early diagnosis, determination of the prognosis and follow-up of patients with HNSCC. In this way, the physicians will have more tools to adequate the therapeutics to the biologic aggressiveness of the lesion. Promoter hypermethylation is considered a tumor marker for different cancer types, including HNSCC. For this reason, the objective of this study is to analyze the methylation profile of target genes in HNSCC samples (tissue, saliva and serum) and verify the utility of this profile as prognostic marker in HNSCC. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
LESSA, ROBERTA C.;
CAMPOS, ANTONIO HUGO J. F. M.;
DE FREITAS, CARLOS ELIAS;
DA SILVA, FELIPE RODRIGUES;
KOWALSKI, LUIZ PAULO;
CARVALHO, ANDRE LOPES;
VETTORE, ANDRE LUIZ.
Identification of upregulated genes in oral squamous cell carcinomas.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,
Web of Science Citations: 19.