Evaluation of methylation profile as prognostic marker in patients with head and neck tumors

• Grant number: 05/02580-8
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2006
• End date: August 31, 2008
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Andre Luiz Vettore de Oliveira
• Grantee: Andre Luiz Vettore de Oliveira
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Head and neck cancer is one of the most frequent cancers in the world and squamous cell carcinoma is the most common variant of this kink of cancer. The therapeutic strategy to head and neck squamous cell carcinoma (HNSCC) is based on tumor site and TNM stage. However, in many cases, tumors showing the same clinical stage and treated by the same approach, have different recurrence profiles and risk to death. An improvement in the actual knowledge about the biologic behavior of HNSCC may conduct to a clearest delineation of the tumor potential of invasion and metastatization. So that, the current efforts are to develop laboratory methodologies to help in the early diagnosis, determination of the prognosis and follow-up of patients with HNSCC. In this way, the physicians will have more tools to adequate the therapeutics to the biologic aggressiveness of the lesion. Promoter hypermethylation is considered a tumor marker for different cancer types, including HNSCC. For this reason, the objective of this study is to analyze the methylation profile of target genes in HNSCC samples (tissue, saliva and serum) and verify the utility of this profile as prognostic marker in HNSCC. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RETTORI, MARIANNA MARCONATO; DE CARVALHO, ANA CAROLINA; BOMFIM LONGO, ANA LUIZA; DE OLIVEIRA, CLEYTON ZANARDO; KOWALSKI, LUIZ PAULO; CARVALHO, ANDRE LOPES; VETTORE, ANDRE LUIZ. Prognostic significance of TIMP3 hypermethylation in post-treatment salivary rinse from head and neck squamous cell carcinoma patients. Carcinogenesis, v. 34, n. 1, p. 20-27, JAN 2013. (05/02580-8)

LESSA, ROBERTA C.; CAMPOS, ANTONIO HUGO J. F. M.; DE FREITAS, CARLOS ELIAS; DA SILVA, FELIPE RODRIGUES; KOWALSKI, LUIZ PAULO; CARVALHO, ANDRE LOPES; VETTORE, ANDRE LUIZ. Identification of upregulated genes in oral squamous cell carcinomas. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 35, n. 10, p. 1475-1481, OCT 2013. (05/02580-8)

PEREIRA, CLAUDIA MARIA; DE CARVALHO, ANA CAROLINA; DA SILVA, FELIPE RODRIGUES; MELENDEZ, MATIAS ELISEO; LESSA, ROBERTA CARDIM; ANDRADE, VALERIA CRISTINA C.; KOWALSKI, LUIZ PAULO; VETTORE, ANDRE L.; CARVALHO, ANDRE LOPES. In vitro and in silico validation of CA3 and FHL1 downregulation in oral cancer. BMC CANCER, v. 18, FEB 17 2018. (05/02580-8)

BOMFIM LONGO, ANA LUIZA; RETTORI, MARIANNA M.; DE CARVALHO, ANA CAROLINA; KOWALSKI, LUIZ PAULO; CARVALHO, ANDRE LOPES; VETTORE, ANDRE LUIZ. Evaluation of the methylation profile of exfoliated cell samples from patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 36, n. 5, p. 631-637, MAY 2014. (05/02580-8)