Investigation of the genotoxic potential of artesunate, artemisinin, 4-hydroxicumarin and sculetin: in vitro mutagenesis methodology implantation

• Grant number: 10/07577-3
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Biological Sciences - Genetics - Mutagenesis
• Principal Investigator: Edson Luis Maistro
• Grantee: Edson Luis Maistro
• Host Institution: Faculdade de Filosofia e Ciências (FFC). Universidade Estadual Paulista (UNESP). Campus de Marília. Marília , SP, Brazil
• Associated researchers: Mário Sérgio Mantovani

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FEDATO, RAFAEL PALHANO; MAISTRO, EDSON LUIS. Absence of genotoxic effects of the coumarin derivative 4-methylesculetin in vivo and its potential chemoprevention against doxorubicin-induced DNA damage. JOURNAL OF APPLIED TOXICOLOGY, v. 34, n. 1, p. 33-39, JAN 2014. (10/07577-3)

MARTINI GONCALVES, ALVARO LUIZ; LEMOS, MARIVANE; NIERO, RIVALDO; DE ANDRADE, SERGIO FALONI; MAISTRO, EDSON LUIS. Evaluation of the genotoxic and antigenotoxic potential of Brassica oleracea L. var. acephala D.C. in different cells of mice. Journal of Ethnopharmacology, v. 143, n. 2, p. 740-745, SEP 28 2012. (10/07577-3)

AQUINO, I.; TSUBOY, M. S. F.; MARCARINI, J. C.; MANTOVANI, M. S.; PERAZZO, F. F.; MAISTRO, E. L.. Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions. Genetics and Molecular Research, v. 12, n. 3, p. 2517-2527, 2013. (10/07577-3)

COSTA RODRIGUES ALVES, ANA BEATRIZ; DOS SANTOS, RAFAELLA SOUZA; CALIL, SUSANA DE SANTANA; NIERO, RIVALDO; LOPES, JHONNY DA SILVA; PERAZZO, FABIO E.; PIRES ROSA, PAULO CESAR; ANDRADE, SERGIO FALONI; CECHINEL-FILHO, VALDIR; MAISTRO, EDSON LUIS. Genotoxic assessment of Rubus imperialis (Rosaceae) extract in vivo and its potential chemoprevention against cyclophosphamide-induced DNA damage. Journal of Ethnopharmacology, v. 153, n. 3, p. 694-700, MAY 14 2014. (10/07577-3)

MAISTRO, EDSON LUIS; MARQUES, EDUARDO DE SOUZA; FEDATO, RAFAEL PALHANO; TOLENTINO, FLORA; CEZARIO DA SILVA, CHAYENE DE ANDRADE; FERREIRA TSUBOY, MARCELA STEFANINI; RESENDE, FLAVIA APARECIDA; VARANDA, ELIANA APARECIDA. In Vitro Assessment of Mutagenic And Genotoxic Effects of Coumarin Derivatives 6,7-Dihydroxycoumarin and 4-Methylesculetin. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 78, n. 2, p. 109-118, JAN 17 2015. (12/17241-8, 10/07577-3)

MARQUES, EDUARDO DE SOUZA; SALLES, DAIANE BERNARDONI; MAISTRO, EDSON LUIS. Assessment of the genotoxic/clastogenic potential of coumarin derivative 6,7-dihydroxycoumarin (aesculetin) in multiple mouse organs. TOXICOLOGY REPORTS, v. 2, p. 268-274, 2015. (10/07577-3)