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Study of the involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus

Grant number: 07/01174-1
Support type:Regular Research Grants
Duration: March 01, 2008 - February 28, 2010
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Norberto Cysne Coimbra
Grantee:Norberto Cysne Coimbra
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Scientific publications (27)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
URIBE-MARINO, ANDRES; CASTIBLANCO-URBINA, MARIA ANGELICA; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; DE OLIVEIRA, RITHIELE CRISTINA; MENDES-GOMES, JOYCE; SOARES, JR., RAIMUNDO DA SILVA; MATTHIESEN, MELINA; ALMADA, RAFAEL CARVALHO; DE OLIVEIRA, RICARDO; COIMBRA, NORBERTO CYSNE. The alpha- and beta-noradrenergic receptors blockade in the dorsal raphe nucleus impairs the panic-like response elaborated by medial hypothalamus neurons. Brain Research, v. 1725, DEC 15 2019. Web of Science Citations: 0.
CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; DA SILVA, JULIANA ALMEIDA; MEDEIROS, PRISCILA; SOARES, JR., RAIMUNDO DA SILVA; DE PAIVA, YARA BEZERRA; RONCON, CAMILA MARRONI; COIMBRA, NORBERTO CYSNE. The Blockade of mu(1)- and kappa-Opioid Receptors in the Inferior Colliculus Decreases the Expression of Panic Attack-Like Behaviours Induced by Chemical Stimulation of the Dorsal Midbrain. NEUROPSYCHOBIOLOGY, v. 78, n. 4, p. 218-228, NOV 2019. Web of Science Citations: 0.
SOARES, JR., RAIMUNDO DA SILVA; FALCONI-SOBRINHO, LUIZ LUCIANO; ALMADA, RAFAEL CARVALHO; COIMBRA, NORBERTO CYSNE. Dorsal raphe nucleus 5-Hydroxytryptamine 2A receptors are critical for the organisation of panic attack-like defensive behaviour and unconditioned fear-induced antinociception elicited by the chemical stimulation of superior colliculus neurons. European Neuropsychopharmacology, v. 29, n. 7, p. 858-870, JUL 2019. Web of Science Citations: 1.
CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; FALCONI-SOBRINHO, LUIZ LUCIANO; PASCHOALIN-MAURIN, TATIANA; BAZAGLIA-DE-SOUSA, GUILHERME; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; LOBAO-SOARES, BRUNO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effect of mu(1)-opioid receptor blockade in the inferior colliculus of prey threatened by Crotalus durissus terrificus pit vipers. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 5, p. 577-588, MAY 2019. Web of Science Citations: 2.
MATIAS, JR., IVAIR; ELIAS, DAOUD HIBRAHIM; BERNARDINO GARCIA, CAMILA ARAUJO; SILVA, GUILHERME HENRIQUE; MEJIA, JORGE; CABRAL, FRANCISCO ROMERO; CAMARGO MIRANDA, ANA CLAUDIA; DA SILVA, SERGIO GOMES; LOPES, LUIZA DA SILVA; COIMBRA, NORBERTO CYSNE; MACHADO, HELIO RUBENS. A new model of experimental hemispherotomy in young adult Rattus norvegicus: a neural tract tracing and SPECT in vivo study. JOURNAL OF NEUROSURGERY, v. 130, n. 4, p. 1210-1223, APR 2019. Web of Science Citations: 1.
SOARES JR, RAIMUNDO DA SILVA; FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus. Behavioural Brain Research, v. 357, n. SI, p. 71-81, JAN 14 2019. Web of Science Citations: 4.
CALVO, FABRICIO; LOBAO-SOARES, BRUNO; DE FREITAS, RENATO LEONARDO; PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; LOVICK, THELMA ANDERSON; COIMBRA, NORBERTO CYSNE. The endogenous opioid system modulates defensive behavior evoked by Crotalus durissus terrificus: Panicolytic-like effect of intracollicular non-selective opioid receptors blockade. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 1, p. 51-61, JAN 2019. Web of Science Citations: 4.
DA SILVA, JULIANA ALMEIDA; ALMADA, RAFAEL CARVALHO; DE FIGUEIREDO, REBECA MACHADO; COIMBRA, NORBERTO CYSNE. Blockade of synaptic activity in the neostriatum and activation of striatal efferent pathways produce opposite effects on panic attack-like defensive behaviours evoked by GABAergic disinhibition in the deep layers of the superior colliculus. Physiology & Behavior, v. 196, p. 104-111, NOV 1 2018. Web of Science Citations: 1.
PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; CYSNE COIMBRA, JADE PISSAMIGLIO; LAURE, CARLOS JULIO; COIMBRA, NORBERTO CYSNE. The Rodent-versus-wild Snake Paradigm as a Model for Studying Anxiety- and Panic-like Behaviors: Face, Construct and Predictive Validities. Neuroscience, v. 369, p. 336-349, JAN 15 2018. Web of Science Citations: 10.
FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; DE OLIVEIRA, RICARDO; COIMBRA, NORBERTO CYSNE. Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited by GABAergic tonic inhibition impairment in the posterior hypothalamus. European Neuropsychopharmacology, v. 27, n. 11, p. 1120-1131, NOV 2017. Web of Science Citations: 8.
DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus. Psychopharmacology, v. 234, n. 20, p. 3009-3025, OCT 2017. Web of Science Citations: 6.
COIMBRA, NORBERTO CYSNE; CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; FREITAS, RENATO LEONARDO; PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; UBIALI, WALTER ADRIANO; LOBAO-SOARES, BRUNO; TRACEY, IRENE. OPIOID NEUROTRANSMISSION MODULATES DEFENSIVE BEHAVIOR AND FEAR-INDUCED ANTINOCICEPTION IN DANGEROUS ENVIRONMENTS. Neuroscience, v. 354, p. 178-195, JUN 23 2017. Web of Science Citations: 15.
ULLAH, FARHAD; DOS ANJOS-GARCIA, TAYLLON; MENDES-GOMES, JOYCE; HIBRAHIM ELIAS-FILHO, DAOUD; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; KHAN, ASMAT ULLAH; DE OLIVEIRA, RICARDO; COIMBRA, NORBERTO CYSNE. Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour. Behavioural Brain Research, v. 319, p. 135-147, FEB 15 2017. Web of Science Citations: 14.
DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO CYSNE. CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABA(A) receptor blockade in the dorsomedial division of the ventromedial hypothalamus. Neuropharmacology, v. 113, n. A, p. 156-166, FEB 2017. Web of Science Citations: 17.
FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; COIMBRA, NORBERTO CYSNE. Unravelling cortico-hypothalamic pathways regulating unconditioned fear-induced antinociception and defensive behaviours. Neuropharmacology, v. 113, n. A, p. 367-385, FEB 2017. Web of Science Citations: 15.
DE OLIVEIRA, RICARDO; DE OLIVEIRA, RITHIELE CRISTINA; FALCONI-SOBRINHO, LUIZ LUCIANO; SOARES, JR., RAIMUNDO DA SILVA; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine(2A/2C) receptors of nucleus raphe magnus and gigantocellularis/paragigantocellularis pars alpha reticular nuclei modulate the unconditioned fear-induced antinociception evoked by electrical stimulation of deep layers of the superior colliculus and dorsal periaqueductal grey matter. Behavioural Brain Research, v. 316, p. 294-304, JAN 1 2017. Web of Science Citations: 9.
BIAGIONI, AUDREY FRANCESCHI; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; DA SILVA, JULIANA ALMEIDA; DOS ANJOS-GARCIA, TAYLION; RONCON, CAMILA MARRONI; CORRADO, ALEXANDRE PINTO; ZANGROSSI, JR., HELIO; COIMBRA, NORBERTO CYSNE. 5-Hydroxytryptamine(1A) receptors in the dorsomedial hypothalamus connected to dorsal raphe nucleus inputs modulate defensive behaviours and mediate innate fear-induced antinociception. European Neuropsychopharmacology, v. 26, n. 3, p. 532-545, MAR 2016. Web of Science Citations: 17.
BIAGIONI, AUDREY FRANCISCO; DOS ANJOS-GARCIA, TAYLLON; ULLAH, FARHAD; FISHER, ISAAC RENE; FALCONI-SOBRINHO, LUIZ LUCIANO; DE FREITAS, RENATO LEONARDO; FELIPPOTTI, TATIANA TOCCHINI; COIMBRA, NORBERTO CYSNE. Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test. Behavioural Brain Research, v. 298, n. B, p. 65-77, FEB 1 2016. Web of Science Citations: 15.
ULLAH, FARHAD; DOS ANJOS-GARCIA, TAYLLON; DOS SANTOS, IEDA REGINA; BIAGIONI, AUDREY FRANCISCO; COIMBRA, NORBERTO CYSNE. Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors. Behavioural Brain Research, v. 293, p. 143-152, OCT 15 2015. Web of Science Citations: 26.
DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCISCO; ALMADA, RAFAEL CARVALHO; DE SOUZA CRIPPA, JOSE ALEXANDRE; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; COIMBRA, NORBERTO CYSNE. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. European Journal of Pharmacology, v. 758, p. 153-163, JUL 5 2015. Web of Science Citations: 12.
TEIXEIRA GONCALVES, THAIS CRISTINA; LONDE, ANNA KARLA; PIRES ALBANO, RAFAEL ISAAC; DE ARAUJO JUNIOR, ARTUR TEIXEIRA; AZEREDO, MARIANA DE AGUIAR; BIAGIONI, AUDREY FRANCISCO; FERREIRA VASCONCELLOS, THIAGO HENRIQUE; DOS REIS FERREIRA, CELIO MARCOS; TEIXEIRA, DULCINEA GONCALVES; DE SOUZA CRIPPA, JOSE ALEXANDRE; VIEIRA, DEBORA; COIMBRA, NORBERTO CYSNE. Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system. JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 347, n. 1-2, p. 82-89, DEC 15 2014. Web of Science Citations: 5.
DE FREITAS, RENATO LEONARDO; SALGADO-ROHNER, CARLOS JOSE; CECILIO HALLAK, JAIME EDUARDO; DE SOUZA CRIPPA, JOSE ALEXANDRE; COIMBRA, NORBERTO CYSNE. Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABA(A) receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 16, n. 8, p. 1781-1798, SEP 2013. Web of Science Citations: 23.
DE FREITAS, RENATO LEONARDO; BOLOGNESI, LUANA IACOVELO; TWARDOWSCHY, ANDRE; AGUIAR CORREA, FERNANDO MORGAN; SIBSON, NICOLA R.; COIMBRA, NORBERTO CYSNE. Neuroanatomical and neuropharmacological approaches to postictal antinociception-related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors. BRAIN AND BEHAVIOR, v. 3, n. 3, p. 286-301, MAY 2013. Web of Science Citations: 10.
BIAGIONI, AUDREY FRANCISCO; DE FREITAS, RENATO LEONARDO; DA SILVA, JULIANA ALMEIDA; DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; ALVES, VANI MARIA; COIMBRA, NORBERTO CYSNE. Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways. Neuropharmacology, v. 67, p. 379-394, APR 2013. Web of Science Citations: 29.
SOUZA DA SILVA, LUIS FELIPE; COIMBRA, NORBERTO CYSNE; MENESCAL-DE-OLIVEIRA, LEDA. Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: A biotinylated dextran amine neurotracing study. Neuroscience Letters, v. 535, p. 116-121, FEB 22 2013. Web of Science Citations: 5.
DA SILVA, JULIANA ALMEIDA; DE FREITAS, RENATO LEONARDO; DUTRA EICHENBERGER, GUSTAVO CAVALCANTI; PADOVAN, CLAUDIA MARIA; COIMBRA, NORBERTO CYSNE. Chemical neuroanatomical and psychopharmacological evidence that kappa receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. European Journal of Pharmacology, v. 698, n. 1-3, p. 235-245, JAN 5 2013. Web of Science Citations: 13.

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