Interactions between membranes, biomolecules and surfaces

• Grant number: 11/00046-5
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2011
• End date: March 31, 2014
• Field of knowledge: Biological Sciences - Biophysics - Molecular Biophysics
• Principal Investigator: Ana Maria Carmona-Ribeiro
• Grantee: Ana Maria Carmona-Ribeiro
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Physico-chemical factors that determine interactions between bilayer vesicles, biomolecules and surfaces are poorly understood. Research will be focused on the following interactions: 1) synthetic bilayer vesicles and oppositely charged polystyrene microspheres or polymeric films; 2) antimicrobial cationic vesicles and cell surfaces of clinically important microorganisms such as bacteria and fungi; 3) phospholipid or synthetic vesicles and mineral surfaces; 4) cationic vesicles and oppositely charged biomolecules such as serum proteins or DNA. The results may be of importance for strategic applied areas (design of vaccines, novel and unexpensive drug delivery agents, biosensors and immunological kits, water treatment and gene therapy). (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE MELO CARRASCO, LETICIA DIAS; MELLO SAMPAIO, JORGE LUIZ; CARMONA-RIBEIRO, ANA MARIA. Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 3, p. 6337-6352, 2015. (12/24534-1, 11/00046-5)

RAGIOTO, DANIELLE A. M. T.; CARRASCO, LETICIA D. M.; CARMONA-RIBEIRO, ANA M.. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 9, p. 3183-3192, 2014. (12/24534-1, 11/00046-5)

NAVES, ALLINY F.; PALOMBO, RENATA R.; CARRASCO, LETICIA D. M.; CARMONA-RIBEIRO, ANA M.. Antimicrobial Particles from Emulsion Polymerization of Methyl Methacrylate in the Presence of Quaternary Ammonium Surfactants. Langmuir, v. 29, n. 31, p. 9677-9684, AUG 6 2013. (12/24534-1, 11/00046-5)

DE MELO CARRASCO, LETICIA DIAS; MELLO SAMPAIO, JORGE LUIZ; CARMONA-RIBEIRO, ANA MARIA. Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 3, p. 16-pg., 2015-03-01. (11/00046-5, 12/24534-1)

RAGIOTO, DANIELLE A. M. T.; CARRASCO, LETICIA D. M.; CARMONA-RIBEIRO, ANA M.. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 9, p. 10-pg., 2014-01-01. (11/00046-5, 12/24534-1)

SANCHES, LUCCAS MISSFELDT; SIQUEIRA PETRI, DENISE FREITAS; DE MELO CARRASCO, LETICIA DIAS; CARMONA-RIBEIRO, ANA MARIA. The antimicrobial activity of free and immobilized poly (diallyldimethylammonium) chloride in nanoparticles of poly (methylmethacrylate). JOURNAL OF NANOBIOTECHNOLOGY, v. 13, SEP 24 2015. (12/24534-1, 11/00046-5)

SILVA, RUBENS A.; CARMONA-RIBEIRO, ANA M.; PETRI, DENISE F. S.. Catalytic Behavior of Lipase Immobilized onto Congo Red and PEG-Decorated Particles. Molecules, v. 19, n. 6, p. 8610-8628, JUN 2014. (11/00046-5)

PUEYO, MANUEL T.; MUTAFCI, BRUNA A.; SOTO-ARRIAZA, MARCO A.; DI MASCIO, PAOLO; CARMONA-RIBEIRO, ANA M.. The Self-Assembly of a Cyclic Lipopeptides Mixture Secreted by a B. megaterium Strain and Its Implications on Activity against a Sensitive Bacillus Species. PLoS One, v. 9, n. 5, MAY 9 2014. (12/12663-1, 06/56530-4, 11/00046-5, 13/07937-8)

Filed patent(s) as a result of this research project