Identification of mechanisms responsible for beneficial effects of calorie restriction

• Grant number: 10/52557-0
• Support Opportunities: Research Grants - Young Investigators Grants
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Marcelo Alves da Silva Mori
• Grantee: Marcelo Alves da Silva Mori
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated scholarship(s): 15/04264-8 - Phenotypic screen of nematodes C. elegans mutants for proteins necessary to systemic RNAi, BP.MS; 14/25068-0 - Unraveling new mechanisms responsible for the cell non-autonomous control of proteostasis in C. elegans, BP.MS; 15/03292-8 - Study of the role of GCN1 in the genesis of metabolic diseases in mice, BP.DR; + associated scholarships 14/25270-3 - Study of Dicer effects on mitochondrial function, metabolism and aging in nematodes C. elegans, BP.MS; 14/12819-7 - Effects of Dicer overexpression on adipocyte differentiation, BP.IC; 14/10814-8 - Determination of factors that controls Dicer expression in vivo in C. elegans, BP.MS; 14/06124-6 - Study of the transgenerational effects of caloric restriction on nematodes C. elegans, BP.IC; 11/24109-6 - The role of Dicer in adipose tissue in aging, stress response and in the effects of caloric restriction in mice, BP.PD; 12/07259-7 - Evaluation of miRNA Processing in Adipose Tissue of Mice Subjected to Caloric Restriction, BP.MS; 12/06238-6 - Dicer deletion in adipocytes and its influence in cardiovascular diseases, BP.PD; 12/04079-8 - Identification of mechanisms responsible for the beneficial effects of caloric restriction, BP.DR; 12/04064-0 - Search for a pharmacological intervention to mimic the beneficial effects of caloric restriction in C. elegans, BP.IC - associated scholarships

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVERIO, MATTEO; SCHMIDT, ELENA; MAUER, JAN; BAITZEL, CATHERINA; HANSMEIER, NILS; KHANI, SAJJAD; KONIECZKA, SANDRA; PRADAS-JUNI, MARTA; BRODESSER, SUSANNE; VAN, TRIEU-MY; et al. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nature Cell Biology, v. 18, n. 3, p. 328+, MAR 2016. (10/52557-0)

REIS, FELIPE C. G.; BRANQUINHO, JESSICA L. O.; BRANDAO, BRUNA B.; GUERRA, BEATRIZ A.; SILVA, ISMAEL D.; FRONTINI, ANDREA; THOMOU, THOMAS; SARTINI, LORIS; CINTI, SAVERIO; KAHN, C. RONALD; et al. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. AGING-US, v. 8, n. 6, p. 1201-1222, JUN 2016. (10/52557-0, 15/01316-7, 11/24109-6)

MORI, MARCELO A.; THOMOU, THOMAS; BOUCHER, JEREMIE; LEE, KEVIN Y.; LALLUKKA, SUSANNA; KIM, JASON K.; TORRIANI, MARTIN; YKI-JAERVINEN, HANNELE; GRINSPOON, STEVEN K.; CYPESS, AARON M.; et al. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. Journal of Clinical Investigation, v. 124, n. 8, p. 3339-3351, AUG 2014. (10/52557-0)

DE-SOUZA, EVANDRO A.; CAMARA, HENRIQUE; SALGUEIRO, WILLIAN G.; MORO, RAISSA P.; KNITTEL, THIAGO L.; TONON, GUILHERME; PINTO, SILAS; PINCA, ANA PAULA F.; ANTEBI, ADAM; PASQUINELLI, AMY E.; et al. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. Nucleic Acids Research, v. 47, n. 8, p. 3957-3969, MAY 7 2019. (12/00195-3, 10/52557-0, 17/22057-5, 17/04377-2, 17/03423-0, 16/02207-0, 17/08829-5, 15/01316-7, 17/01339-2, 14/10814-8, 17/01184-9, 14/25068-0, 16/15958-3)

GUERRA, BEATRIZ A.; BRANDAO, BRUNA B.; PINTO, SILAS S.; SALGUEIRO, WILLIAN G.; DE-SOUZA, EVANDRO A.; REIS, FELIPE C. G.; BATISTA, THIAGO M.; CAVALCANTE-SILVA, VANESSA; D'ALMEIDA, VANIA; CASTILHO, BEATRIZ A.; et al. Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects. MOLECULAR METABOLISM, v. 29, p. 124-135, NOV 2019. (15/03292-8, 17/22057-5, 10/52557-0, 16/02207-0, 17/01184-9, 15/01316-7, 15/19530-5, 12/07259-7, 17/07975-8)

ROCHA, ANDREA LIVIA; DE LIMA, TANES IMAMURA; DE SOUZA, GERSON PROFETA; CORREA, RENAN OLIVEIRA; FERRUCCI, DANILO LOPES; RODRIGUES, BRUNO; LOPES-RAMOS, CAMILA; NILSSON, DANIEL; KNITTEL, THIAGO LEITE; CASTRO, POLLYANA RIBEIRO; et al. Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. SCIENCE ADVANCES, v. 6, n. 49, DEC 2020. (10/52557-0, 17/01184-9, 18/15313-8, 16/23142-3, 17/07975-8, 16/24163-4, 15/01316-7, 16/12294-7)

PINTO, SILAS; SATO, VITOR N.; DE-SOUZA, EVANDRO A.; FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; PINCA, ANA PAULA F.; MAZZOTTI, DIEGO R.; LOVCI, MICHAEL T.; TONON, GUILHERME; LOPES-RAMOS, CAMILA M.; et al. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. REDOX BIOLOGY, v. 18, p. 84-92, SEP 2018. (12/04064-0, 15/04264-8, 17/04377-2, 15/01316-7, 14/10814-8, 17/01184-9, 12/24490-4, 10/52557-0, 14/25270-3, 14/25068-0)

FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; DE-SOUZA, EVANDRO A.; PINTO, SILAS; PINCA, ANA PAULA F.; SILVA, RICHARD C.; SATO, VITOR N.; CASTILHO, BEATRIZ A.; MORI, MARCELO A.. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biology, v. 14, OCT 7 2016. (10/52557-0, 15/01316-7, 12/24490-4, 14/25270-3, 14/10814-8, 14/17145-4, 09/52047-5, 15/04264-8, 12/04064-0, 14/25068-0)

THOMOU, THOMAS; MORI, MARCELO A.; DREYFUSS, JONATHAN M.; KONISHI, MASAHIRO; SAKAGUCHI, MASAJI; WOLFRUM, CHRISTIAN; RAO, TATA NAGESWARA; WINNAY, JONATHON N.; GARCIA-MARTIN, RUBEN; GRINSPOON, STEVEN K.; et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature, v. 542, n. 7642, p. 450+, FEB 23 2017. (10/52557-0, 15/01316-7)