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Identification of mechanisms responsible for beneficial effects of calorie restriction

Grant number: 10/52557-0
Support Opportunities:Research Grants - Young Investigators Grants
Duration: August 01, 2011 - July 31, 2015
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Marcelo Alves da Silva Mori
Grantee:Marcelo Alves da Silva Mori
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated scholarship(s):15/04264-8 - Phenotypic screen of nematodes C. elegans mutants for proteins necessary to systemic RNAi, BP.MS
14/25068-0 - Unraveling new mechanisms responsible for the cell non-autonomous control of proteostasis in C. elegans, BP.MS
15/03292-8 - Study of the role of GCN1 in the genesis of metabolic diseases in mice, BP.DR
+ associated scholarships 14/25270-3 - Study of Dicer effects on mitochondrial function, metabolism and aging in nematodes C. elegans, BP.MS
14/12819-7 - Effects of Dicer overexpression on adipocyte differentiation, BP.IC
14/10814-8 - Determination of factors that controls Dicer expression in vivo in C. elegans, BP.MS
14/06124-6 - Study of the transgenerational effects of caloric restriction on nematodes C. elegans, BP.IC
11/24109-6 - The role of Dicer in adipose tissue in aging, stress response and in the effects of caloric restriction in mice, BP.PD
12/07259-7 - Evaluation of miRNA Processing in Adipose Tissue of Mice Subjected to Caloric Restriction, BP.MS
12/06238-6 - Dicer deletion in adipocytes and its influence in cardiovascular diseases, BP.PD
12/04079-8 - Identification of mechanisms responsible for the beneficial effects of caloric restriction, BP.DR
12/04064-0 - Search for a pharmacological intervention to mimic the beneficial effects of caloric restriction in C. elegans, BP.IC - associated scholarships
Articles published in Pesquisa FAPESP Magazine about the research grant:
En un gusano, los frenos del envejecimiento 
Worm may help put the brakes on aging 
En un gusano, los frenos del envejecimiento 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REIS, FELIPE C. G.; BRANQUINHO, JESSICA L. O.; BRANDAO, BRUNA B.; GUERRA, BEATRIZ A.; SILVA, ISMAEL D.; FRONTINI, ANDREA; THOMOU, THOMAS; SARTINI, LORIS; CINTI, SAVERIO; KAHN, C. RONALD; et al. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. AGING-US, v. 8, n. 6, p. 1201-1222, . (10/52557-0, 15/01316-7, 11/24109-6)
OLIVERIO, MATTEO; SCHMIDT, ELENA; MAUER, JAN; BAITZEL, CATHERINA; HANSMEIER, NILS; KHANI, SAJJAD; KONIECZKA, SANDRA; PRADAS-JUNI, MARTA; BRODESSER, SUSANNE; VAN, TRIEU-MY; et al. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nature Cell Biology, v. 18, n. 3, p. 328+, . (10/52557-0)
GUERRA, BEATRIZ A.; BRANDAO, BRUNA B.; PINTO, SILAS S.; SALGUEIRO, WILLIAN G.; DE-SOUZA, EVANDRO A.; REIS, FELIPE C. G.; BATISTA, THIAGO M.; CAVALCANTE-SILVA, VANESSA; D'ALMEIDA, VANIA; CASTILHO, BEATRIZ A.; et al. Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects. MOLECULAR METABOLISM, v. 29, p. 124-135, . (15/03292-8, 17/22057-5, 10/52557-0, 16/02207-0, 17/01184-9, 15/01316-7, 15/19530-5, 12/07259-7, 17/07975-8)
DE-SOUZA, EVANDRO A.; CAMARA, HENRIQUE; SALGUEIRO, WILLIAN G.; MORO, RAISSA P.; KNITTEL, THIAGO L.; TONON, GUILHERME; PINTO, SILAS; PINCA, ANA PAULA F.; ANTEBI, ADAM; PASQUINELLI, AMY E.; et al. RNA interference may result in unexpected phenotypes in Caenorhabditis elegans. Nucleic Acids Research, v. 47, n. 8, p. 3957-3969, . (12/00195-3, 10/52557-0, 17/22057-5, 17/04377-2, 17/03423-0, 16/02207-0, 17/08829-5, 15/01316-7, 17/01339-2, 14/10814-8, 17/01184-9, 14/25068-0, 16/15958-3)
MORI, MARCELO A.; THOMOU, THOMAS; BOUCHER, JEREMIE; LEE, KEVIN Y.; LALLUKKA, SUSANNA; KIM, JASON K.; TORRIANI, MARTIN; YKI-JAERVINEN, HANNELE; GRINSPOON, STEVEN K.; CYPESS, AARON M.; et al. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. Journal of Clinical Investigation, v. 124, n. 8, p. 3339-3351, . (10/52557-0)
ROCHA, ANDREA LIVIA; DE LIMA, TANES IMAMURA; DE SOUZA, GERSON PROFETA; CORREA, RENAN OLIVEIRA; FERRUCCI, DANILO LOPES; RODRIGUES, BRUNO; LOPES-RAMOS, CAMILA; NILSSON, DANIEL; KNITTEL, THIAGO LEITE; CASTRO, POLLYANA RIBEIRO; et al. Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. SCIENCE ADVANCES, v. 6, n. 49, . (10/52557-0, 17/01184-9, 18/15313-8, 16/23142-3, 17/07975-8, 16/24163-4, 15/01316-7, 16/12294-7)
THOMOU, THOMAS; MORI, MARCELO A.; DREYFUSS, JONATHAN M.; KONISHI, MASAHIRO; SAKAGUCHI, MASAJI; WOLFRUM, CHRISTIAN; RAO, TATA NAGESWARA; WINNAY, JONATHON N.; GARCIA-MARTIN, RUBEN; GRINSPOON, STEVEN K.; et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature, v. 542, n. 7642, p. 450+, . (10/52557-0, 15/01316-7)
PINTO, SILAS; SATO, VITOR N.; DE-SOUZA, EVANDRO A.; FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; PINCA, ANA PAULA F.; MAZZOTTI, DIEGO R.; LOVCI, MICHAEL T.; TONON, GUILHERME; LOPES-RAMOS, CAMILA M.; et al. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. REDOX BIOLOGY, v. 18, p. 84-92, . (12/04064-0, 15/04264-8, 17/04377-2, 15/01316-7, 14/10814-8, 17/01184-9, 12/24490-4, 10/52557-0, 14/25270-3, 14/25068-0)
FERRAZ, RAFAEL C.; CAMARA, HENRIQUE; DE-SOUZA, EVANDRO A.; PINTO, SILAS; PINCA, ANA PAULA F.; SILVA, RICHARD C.; SATO, VITOR N.; CASTILHO, BEATRIZ A.; MORI, MARCELO A.. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biology, v. 14, . (10/52557-0, 15/01316-7, 12/24490-4, 14/25270-3, 14/10814-8, 14/17145-4, 09/52047-5, 15/04264-8, 12/04064-0, 14/25068-0)

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