Cancer stem cell in locally advanced breast cancer

• Grant number: 11/13020-4
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2011
• End date: June 30, 2014
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Daniel Guimarães Tiezzi
• Grantee: Daniel Guimarães Tiezzi
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Geraldo Aleixo da Silva Passos Júnior ; João Santana da Silva ; Jurandyr Moreira de Andrade ; Valdair Francisco Muglia

Abstract

Breast cancer is the leading cause of malignancy among women worldwide. In Brazil, about 50% of patients present with locally advanced or metastatic disease at the diagnostic. Neoadjuvant chemotherapy has been used as the standard treatment. The pathological response to therapy is an important prognostic factor. Only 20% of patients achieve complete pathological response and do benefit from neoadjuvant therapy in terms of overall survival. Identify prognostic factors of response can optimize the response rate, reduce the cost and adverse effect of treatment.The presence of cancer stem cells (CSCs) within solid tumors has been reported as the cause of tumor heterogeneity and resistance to therapy. Notwithstanding, the CSCs are able to generate tumors at distant organs. Thus, the quantity or the quality of CSCs within the primary tumor could be predictive of response to therapy. Identify and genotype this population of cells is a novel opportunity for response prediction in locally advanced breast cancer and open new perspective to target therapy. The objective of this study is to analyze the CSCs population and some MRI parameters correlating with pathological response to neoadjuvant chemotherapy in breast cancer patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SICCHIERI, RENATA DANIELLE; DA SILVEIRA, WILLIAN ABRAHAM; MOURO MANDARANO, LARISSA RAQUEL; GONCALVES DE OLIVEIRA, TATIANE MENDES; ANGOTTI CARRARA, HELIO HUMBERTO; MUGLIA, VALDAIR FRANCISCO; DE ANDRADE, JURANDYR MOREIRA; TIEZZI, DANIEL GUIMARAES. ABCG2 is a potential marker of tumor-initiating cells in breast cancer. TUMOR BIOLOGY, v. 36, n. 12, p. 9233-9243, DEC 2015. (11/13020-4)