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Metabolic repercussion of physical training-induced AMPK activation in mice submitted to hypercaloric diet

Grant number: 11/02126-6
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Fabiana de Sant'Anna Evangelista
Grantee:Fabiana de Sant'Anna Evangelista
Home Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Changes in muscle metabolism caused by the accumulation of intramuscular lipids are associated with the development of insulin resistance and type 2 diabetes mellitus. One of the possible cellular mechanisms involved in this response is a loss of the action of AMPK (AMP activated protein kinase), protein responsible for activation of pathways that increase the synthesis of ATP as glycolysis and fatty acid oxidation. The high calorie diet and physical training exert antagonistic effects on AMPK activity, but when combined in a previous study conducted by our group (FAPESP 09/52904-5), we found that physical training has the potential sufficient to prevent glucose intolerance and that the AMPK / ACC participates this response and possibly providing more glucose for fatty acid oxidation. However, we do not know what extent the protective effect of exercise training on glucose intolerance is a result of lipid metabolism in skeletal muscle via increased oxidation, or inhibition of lipogenesis, or both. Thus, the present study investigated the effects of AMPK activation induced by physical training on the metabolic phenotype of skeletal muscle of mice subjected to caloric diet. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Study shows how physical activity helps prevent metabolic diseases 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HIGA, T. S.; SPINOLA, A. V.; FONSECA-ALANIZ, M. H.; EVANGELISTA, F. S. Remodeling of white adipose tissue metabolism by physical training prevents insulin resistance. Life Sciences, v. 103, n. 1, p. 41-48, MAY 8 2014. Web of Science Citations: 12.
FIORINO, PATRICIA; EVANGELISTA, FABIANA SANT'ANNA; SANTOS, FERNANDO; MOTTER MAGRI, FATIMA MARIA; DELORENZI, JAN CARLO MORAIS O. B.; GINOZA, MILTON; FARAH, VERA. The Effects of Green Tea Consumption on Cardiometabolic Alterations Induced by Experimental Diabetes. Experimental Diabetes Research, 2012. Web of Science Citations: 7.

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