Effects of concurrent training on inflammatory and morphofunctional responses in obese middle-aged men

• Grant number: 11/09446-6
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2011
• End date: March 31, 2014
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Claudia Regina Cavaglieri
• Grantee: Claudia Regina Cavaglieri
• Host Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Jose Rocha ; Mara Patricia Traina Chacon Mikahil ; Maria Luisa Bellotto Bortoleto

Abstract

The aim of this study is to compare the concurrent training (CT) responses on the biochemical and morphofunctional markers in obese middle-aged men. Forty obese men [body mass index (BMI) =30-34.9 kg/m²] distributed in the obese control group (OCG; n=20) and obese group CT (OCT; n=20) will be recruited. Body composition, cardiorespiratory fitness and muscular strength of individuals will be performed by anthropometric assessment, cardiopulmonary test and one maximum repetition test (1RM), respectively. Blood samples will be collected before the beginning of the study (M1), as well as after 8 (M2), 16 (M3) and 24 weeks (M4), and for each moment resistin, adiponectin, leptin, interleukin (IL) 6 (IL-6), IL-10, IL-15, prostaglandin (PGE2), tumor necrosis factor alpha (TNF-±), C-reactive protein (CRP), cortisol, testosterone, lactate dehydrogenase (LDH), creatine kinase (CK) and complete blood count will be analyzed. The CT program will be composed of both strength (6 exercises/3X10 repetitions/1 minute rest between sets) and endurance (30 minutes walking or running at 50-85% of VO2max) training performed in the same session, three times per week and divided into three phases (E1, E2 and E3), each with eight weeks duration and different intensities. It is expected that the CT protocol can decrease the body fat and the inflammatory biomarkers. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELLOTTO, M. L.; CASTRO, A.; BONFANTE, I. L. P.; BRUNELLI, D. T.; CHACON-MIKAHIL, M. P. T.; CAVAGLIERI, C. R.. Association of food quality index with subclinical inflammation in middle-aged obese men. MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM, v. 14, n. 2, p. 163-171, 2021. (11/09446-6)

PADILHA BONFANTE, IVAN LUIZ; TRAINA CHACON-MIKAHIL, MARA PATRICIA; BRUNELLI, DIEGO TREVISAN; GASPARI, ARTHUR FERNANDES; DUFT, RENATA GARBELLINI; LOPES, WENDELL ARHUR; BONGANHA, VALERIA; LIBARDI, CLEITON AUGUSTO; CAVAGLIERI, CLAUDIA REGINA. Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial. European Journal of Sport Science, v. 17, n. 5, p. 629-637, JUN 2017. (11/09446-6)

PADILHA BONFANTE, IVAN LUIZ; TRAINA CHACON-MIKAHIL, MARA PATRICIA; BRUNELLI, DIEGO TREVISAN; GASPARI, ARTHUR FERNANDES; DUFT, RENATA GARBELLINI; OLIVEIRA, ALEXANDRE GABARRA; ARAUJO, TIAGO GOMES; ABDALLA SAAD, MARIO JOSE; CAVAGLIERI, CLAUDIA REGINA. Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 61, n. 6, p. 10-pg., 2017-12-01. (11/09446-6)

PADILHA BONFANTE, IVAN LUIZ; TRAINA CHACON-MIKAHIL, MARA PATRICIA; BRUNELLI, DIEGO TREVISAN; GASPARI, ARTHUR FERNANDES; DUFT, RENATA GARBELLINI; OLIVEIRA, ALEXANDRE GABARRA; ARAUJO, TIAGO GOMES; ABDALLA SAAD, MARIO JOSE; CAVAGLIERI, CLAUDIA REGINA. Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 61, n. 6, p. 524-533, DEC 2017. (11/09446-6)

BRUNELLI, DIEGO T.; CHACON-MIKAHIL, MARA PATRICIA T.; GASPARI, ARTHUR F.; LOPES, WENDELL ARTHUR; BONGANHA, VALERIA; BONFANTE, IVAN LUIZ P.; BELLOTTO, MARIA LUISA; LIBARDI, CLEITON AUGUSTO; CAVAGLIERI, CLAUDIA REGINA. Combined Training Reduces Subclinical Inflammation in Obese Middle-Age Men. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 47, n. 10, p. 2207-2215, OCT 2015. (11/09446-6)