Effects of concurrent training on serum ghrelin and biomarkers of inflammation in obese men middle age

• Grant number: 13/00813-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2013
• End date: March 31, 2014
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Claudia Regina Cavaglieri
• Grantee: Keryma Chaves da Silva Mateus
• Host Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

It is known that low-grade chronic inflammation is associated with obesity and physical inactivity. By acting as an orexigenic hormone, ghrelin has been studied in protocols of aerobic and anaerobic exercise and interaction with other hormones like insulin and cortisol in combating obesity. However, this hormone responses to aerobic (AT) and resistance training (RT) are controversial. Still, no study was to investigate the response of ghrelin compared to a protocol of concurrent training (CT), which is recommended by world health agencies to maintain and / or improve their health. In this context, the objective of this research will investigate the effects of a program of concurrent training on serum ghrelin and its relationship with inflammatory markers such as tumor necrosis factor-± (TNF-±) in patients with degree 1 obesity. The sample is composed of 40 male subjects with degree 1 obesity [body mass index (BMI) of 30 to 34.9 kg / m²] divided into control group (CG, n = 20) group and concurrent training (CT n = 20). The body composition, cardiorespiratory aptitude and muscle strength indicators of individuals are determined by anthropometric assessment, cardiopulmonary exercise test and one-repetition maximum (1RM), respectively. Blood samples will be collected at baseline (M1)and after 24 weeks (M2), these will be analyzed: ghrelin and TNF-±.The program will consist of CT for conducting the RT and AT in the same session, with a frequency of three times a week, divided into three stages (E1, E2 and E3), each with eight weeks duration and varying intensity. Our hypothesis is that the CT program may increase the serum concentration of ghrelin with consequent reduction in serum levels of TNF-± after the intervention period. (AU)