The diacerein properties on the left ventricle remodeling after acute myocardial infarction: experimental study

• Grant number: 11/14550-7
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2011
• End date: November 30, 2013
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Orlando Petrucci Jr
• Grantee: Orlando Petrucci Jr
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Karlos Alexandre de Sousa Vilarinho

Abstract

Despite improvements in the treatment of acute coronary syndromes, the mortality and morbidity are still high in the real world. The amount of cell death that occurs during and after myocardial ischemia is a key determinant of late outcomes following acute coronary syndromes. In accordance with the World Health Organization, myocardial ischemia is a lethal disease with high social demands. Therefore, reducing the volume of damaged cells after myocardial ischemia and reperfusion is a crucial strategy. The tumor necrosis factor (TNF) participates in several situations where ischemia and reperfusion lesions happen. Some studies have demonstrated the paradoxical effect of tumor necrosis factor after myocardial ischemia/reperfusion. The tumor necrosis factor activation may provide a favorable effect on the myocardial adaptation following an initial ischemia and reperfusion insult. The properties of diacerein have been proposed by an inflammatory response modulation. Diacerein modulates the TNF, IL6, and IL1 secretion by chondrocytes and in the peritoneal fluid of rodents with long-term use of this drug. The inhibition of those cytokines might be helpful for the left ventricle remodeling following an initial ischemia/reperfusion insult of the myocardium. The main objective of this proposal is to determine whether diacerein has beneficial effects after acute myocardial infarction as well as remodeling effects of the left ventricle 4 weeks following the initial event. This study might suggest a novel use of this drug. We are starting from the hypothesis that in a relevant model of myocardial ischemia, the use of diacerein right after acute myocardial infarction and within 4 weeks following the initial event might minimize cell loss, improve ventricular function, and provide a favorable left ventricle remodeling effect. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TORINA, ANALI GALLUCE; REICHERT, KARLA; LIMA, FANY; DE SOUZA VILARINHO, KARLOS ALEXANDRE; MARTINS DE OLIVEIRA, PEDRO PAULO; PEREIRA DO CARMO, HELISON RAFAEL; DE CARVALHO, DANIELA DIOGENES; ABDALLA SAAD, MARIO JOSE; SPOSITO, ANDREI CARVALHO; PETRUCCI, ORLANDO. Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction. PLoS One, v. 10, n. 3, MAR 27 2015. (11/14550-7)

REICHERT, KARLA; PEREIRA DO CARMO, HELISON RAFAEL; TORINA, ANALI GALLUCE; DE CARVALHO, DANIELA DIOGENES; SPOSITO, ANDREI CARVALHO; DE SOUZA VILARINHO, KARLOS ALEXANDRE; SILVEIRA-FILHO, LINDEMBERG DA MOTA; MARTINS DE OLIVEIRA, PEDRO PAULO; PETRUCCI, ORLANDO. Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism. PLoS One, v. 11, n. 11, NOV 23 2016. (11/14550-7, 12/09130-1)