Use of nanoparticles in vaccines against bacterial meningitis

• Grant number: 11/14079-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: January 31, 2014
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Marcelo Lancellotti
• Grantee: Marcelo Lancellotti
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This work aims at the combined use of outer membrane vesicles - OMV, carbon nanotubes and mesoporous silica vaccine in immunization procedures. For this, we use nanoparticles known as OMV, produced by bacteria such as Neisseria meningitidis and Haemophilus influenzae, in new forms of production targeting a broad use of this methodology to obtain these antigenic nanostructures. In addition to the OMVS, we use the multi-layered carbon nanotubes (MWCNT) and mesoporous silica as an adjuvant to enhance immune responses and look for an improved vaccine coverage. This work will develop methods to obtain less costly vaccines that vaccines based on OMVS on the market, aims to obtain since these nanostructures by processes of ultrafiltration, ultracentrifugation dispensing process. This process requires equipment that make it difficult to scale up for production of vaccines, thus increasing the cost of it to the most deprived and exposed to bacterial meningitis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AMSTALDEN, MARIA-CECILIA KRAHENBUEHL; OLIVEIRA, JOSE DIOGO; STRAUSS, MATHIAS; MAZALI, ITALO ODONE; MACHADO, DAISY; THEISEN, THAIS HOLTZ; LANCELLOTTI, MARCELO. Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process. Folia Microbiologica, v. 64, n. 1, p. 127-132, JAN 2019. (14/50906-9, 11/14079-2, 13/22127-2)

JOSÉ DIOGO DE OLIVEIRA; CARLOS FERNANDO MACEDO; JOÃO PAULO DE OLIVEIRA GUARNIERI; THAÍS HOLTZ THEIZEN; DAISY MACHADO; MARCELO LANCELLOTTI. Influence of environmental dust in transformation capacity of Streptococcus pneumoniae. GENETICS AND MOLECULAR BIOLOGY, v. 44, n. 1, 2020-12-11. (12/15046-3, 18/09874-7, 11/14079-2)

VARELA, JULIA NOGUEIRA; KRAEHENBUEHL AMSTALDEN, MARIA CECILIA; CARNEIRO PEREIRA, RAFAELLA FABIANA; DE HOLLANDA, LUCIANA MARIA; CERAGIOLI, HELDER JOSE; BARANAUSKAS, VITOR; LANCELLOTTI, MARCELO. Haemophilus influenzae porine ompP2 gene transfer mediated by graphene oxide nanoparticles with effects on transformation process and virulence bacterial capacity. JOURNAL OF NANOBIOTECHNOLOGY, v. 12, APR 16 2014. (11/21685-6, 11/14079-2, 12/15046-3)

Filed patent(s) as a result of this research project