Determination of tertiary structure in solution of the tegumentar protein Sm8 from Schistosoma mansoni by using NMR methods

• Grant number: 11/19149-9
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Alviclér Magalhães
• Grantee: Alviclér Magalhães
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The Sm8 is a tegument protein from Schistosoma mansoni that cause Schistosomiasis. Studies show that there is cross-reactivity of this protein in mice activating the immune system against this parasite. In this project we will determine the tertiary structure of tegument protein (Sm8) in solution using NMR. With the knowledge of the structure of this protein we can make a better description of its function and provide input into the formulation of vaccines or drugs that may inhibit the growth of the parasite or even exterminate them in human hosts. (AU)