Chemical Study of the leaves from Vochysia divergens and evaluation of its schistossomicidal potential

• Grant number: 11/23451-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): February 01, 2012
• Effective date (End): December 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ana Helena Januário
• Grantee: Maroli Rodrigues da Silva
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

This scientific initiation project intends to realize the chemistry study of the leaves from Vochysia divergens Pohl (Vochysiaceae), a native food species from the Pantanal Biome. This region has been selected for study within the Regular Research Project "Bioactive compounds from medicinal and food plants of the Cerrado and Pantanal and their endophytic microbiota (Fapesp Process # 2011/00631-5).The phytochemistry research will be bioassay-guided by the schistosomicidal in vitro assay. The schistosomicidal test will be held to evaluate the life cycle of the Schistosoma mansoni vector. The analytical methodologies will employ chromatography techniques (CC, PTLC, GC-MS, HPLC-DAD). The chemical structures of the isolated compounds will the assign on the bases of 1D and 2D NMR experiments. Thus, the main goal of this proposal will be to identify the potential schistosomicidal of natural compounds, as well as contribute to the human resource formation in the natural product area in the Northeastern São Paulo State.(AU)