Characterization and control of cellular internalization process of nanoparticles

• Grant number: 11/23895-8
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: May 01, 2012
• End date: April 30, 2016
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Dayane Batista Tada
• Grantee: Dayane Batista Tada
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
• Associated researchers: Alisson Leonardo Matsuo ; Denise Costa Arruda ; Eudes Eterno Fileti ; Flávio Aimbire Soares de Carvalho ; Helena Couto Junqueira ; Luiz Rodolpho Raja Gabaglia Travassos ; Matheus Sacilotto de Moura ; Rosangela Itri ; Tatiane Moraes Arantes ; Tiago dos Santos Rodrigues
• Associated scholarship(s): 15/11281-6 - Studies of interactions between nanoparticles and biomolecules through surface plasmon resonance, BP.IC; 14/17491-0 - Synthesis and functionalization of nanoparticles, BP.IC

Abstract

The present project aims at characterizing the cellular internalization of Nanoparticles (NPs). It has been demonstrated that NPs therapeutic efficiency and toxicity depend on their cytolocalization, which in turn, is defined by their internalization process. To study the interaction of NPs in biological systems, we will use a murine melanoma model system. The development of this project can provide useful information about NPs interaction with biomolecules, membrane and cells. NPs will be synthesized with different parameters in order to obtain high therapeutic efficiency and low toxicity.The use of NPs synthesis and NPs surface modification techniques in order to target a tumor cell and the controlled intracellular destination coupled with the understanding of chemical and biomolecular interactions between NPs and biological systems are important features of this project. Experiments proposed here may lead to the development of highly efficient NPs for melanoma therapy. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TADA, DAYANE B.; BAPTISTA, MAURICIO S.. Photosensitizing nanoparticles and the modulation of ROS generation. FRONTIERS IN CHEMISTRY, v. 3, MAY 27 2015. (11/23895-8, 13/07937-8, 12/50680-5)

DE OLIVEIRA, THAIS DOLZANY; TRAVASSOS, LUIZ R.; ARRUDA, DENISE COSTA; TADA, DAYANE BATISTA. Intracellular Targeting of Poly Lactic-Co-Glycolic Acid Nanoparticles by Surface Functionalization with Peptides. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 17, n. 7, p. 1320-1329, JUL 2021. (11/23895-8, 15/05980-9, 17/01697-6, 18/11972-7, 10/51423-0)

DO NASCIMENTO POMARI, ANDREIA APARECIDA; DO AMARAL MONTANHEIRO, THAIS LARISSA; DE SIQUEIRA, CRISTIANE PEREIRA; SILVA, RODRIGO SOUSA; TADA, DAYANE BATISTA; LEMES, ANA PAULA. Chitosan Hydrogels Crosslinked by Genipin and Reinforced with Cellulose Nanocrystals: Production and Characterization. JOURNAL OF COMPOSITES SCIENCE, v. 3, n. 3, p. 12-pg., 2019-09-01. (11/23895-8, 13/27064-9)

DE MACEDO, ERENILDO FERREIRA; DUCATTI FORMAGGIO, DANIELA MARIA; SANTOS, NIVIA SALLES; TADA, DAYANE BATISTA. Gold Nanoparticles Used as Protein Scavengers Enhance Surface Plasmon Resonance Signal. SENSORS, v. 17, n. 12, DEC 2017. (11/23895-8, 17/01697-6)

ARRUDA, DENISE COSTA; DE OLIVEIRA, THAIS DOLZANY; FUKUDA CURSINO, PATRICIA HARUME; CARNEIRO MAIA, VERA SUSANA; BERZAGHI, RODRIGO; TRAVASSOS, LUIZ R.; TADA, DAYANE BATISTA. Inhibition of melanoma metastasis by dual-peptlde PLGA NPS. Biopolymers, v. 108, n. 5, SEP 2017. (11/23895-8, 15/05980-9, 10/51423-0)

DUCATTI FORMAGGIO, DANIELA MARIA; DE OLIVEIRA NETO, XISTO ANTONIO; ALCANTARA RODRIGUES, LINA DAYSE; DE ANDRADE, VITOR MARTINS; NUNES, BRUNA C.; LOPES-FERREIRA, MONICA; FERREIRA, FABIANA G.; WACHESK, CRISTIANE C.; CAMARGO, EMERSON R.; CONCEICAO, KATIA; et al. In vivo toxicity and antimicrobial activity of AuPt bimetallic nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 21, n. 11, NOV 2019. (11/23895-8, 17/01697-6)

BRAGA, NATALIA F.; VITAL, DANIEL A.; GUERRINI, LILIA M.; LEMES, ANA P.; FORMAGGIO, DANIELA M. D.; TADA, DAYANE B.; ARANTES, TATIANE M.; CRISTOVAN, FERNANDO H.. PHBV-TiO2 mats prepared by electrospinning technique: Physico-chemical properties and cytocompatibility. Biopolymers, v. 109, n. 5, MAY 2018. (11/23895-8)

TADA, DAYANE B.; BAPTISTA, MAURICIO S.. Photosensitizing nanoparticles and the modulation of ROS generation. RONTIERS IN CHEMISTR, v. 3, p. 14-pg., 2015-05-27. (13/07937-8, 11/23895-8, 12/50680-5)