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Characterization and control of cellular internalization process of nanoparticles

Abstract

The present project aims at characterizing the cellular internalization of Nanoparticles (NPs). It has been demonstrated that NPs therapeutic efficiency and toxicity depend on their cytolocalization, which in turn, is defined by their internalization process. To study the interaction of NPs in biological systems, we will use a murine melanoma model system. The development of this project can provide useful information about NPs interaction with biomolecules, membrane and cells. NPs will be synthesized with different parameters in order to obtain high therapeutic efficiency and low toxicity.The use of NPs synthesis and NPs surface modification techniques in order to target a tumor cell and the controlled intracellular destination coupled with the understanding of chemical and biomolecular interactions between NPs and biological systems are important features of this project. Experiments proposed here may lead to the development of highly efficient NPs for melanoma therapy. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TADA, DAYANE B.; BAPTISTA, MAURICIO S.. Photosensitizing nanoparticles and the modulation of ROS generation. FRONTIERS IN CHEMISTRY, v. 3, . (12/50680-5, 11/23895-8, 13/07937-8)
DE OLIVEIRA, THAIS DOLZANY; TRAVASSOS, LUIZ R.; ARRUDA, DENISE COSTA; TADA, DAYANE BATISTA. Intracellular Targeting of Poly Lactic-Co-Glycolic Acid Nanoparticles by Surface Functionalization with Peptides. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 17, n. 7, p. 1320-1329, . (11/23895-8, 15/05980-9, 17/01697-6, 18/11972-7, 10/51423-0)
BRAGA, NATALIA F.; VITAL, DANIEL A.; GUERRINI, LILIA M.; LEMES, ANA P.; FORMAGGIO, DANIELA M. D.; TADA, DAYANE B.; ARANTES, TATIANE M.; CRISTOVAN, FERNANDO H.. PHBV-TiO2 mats prepared by electrospinning technique: Physico-chemical properties and cytocompatibility. Biopolymers, v. 109, n. 5, . (11/23895-8)
ARRUDA, DENISE COSTA; DE OLIVEIRA, THAIS DOLZANY; FUKUDA CURSINO, PATRICIA HARUME; CARNEIRO MAIA, VERA SUSANA; BERZAGHI, RODRIGO; TRAVASSOS, LUIZ R.; TADA, DAYANE BATISTA. Inhibition of melanoma metastasis by dual-peptlde PLGA NPS. Biopolymers, v. 108, n. 5, . (11/23895-8, 10/51423-0, 15/05980-9)
DUCATTI FORMAGGIO, DANIELA MARIA; DE OLIVEIRA NETO, XISTO ANTONIO; ALCANTARA RODRIGUES, LINA DAYSE; DE ANDRADE, VITOR MARTINS; NUNES, BRUNA C.; LOPES-FERREIRA, MONICA; FERREIRA, FABIANA G.; WACHESK, CRISTIANE C.; CAMARGO, EMERSON R.; CONCEICAO, KATIA; et al. In vivo toxicity and antimicrobial activity of AuPt bimetallic nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 21, n. 11, . (11/23895-8, 17/01697-6)
DE MACEDO, ERENILDO FERREIRA; DUCATTI FORMAGGIO, DANIELA MARIA; SANTOS, NIVIA SALLES; TADA, DAYANE BATISTA. Gold Nanoparticles Used as Protein Scavengers Enhance Surface Plasmon Resonance Signal. SENSORS, v. 17, n. 12, . (11/23895-8, 17/01697-6)

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