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Characterization and control of cellular internalization process of nanoparticles

Grant number: 11/23895-8
Support type:Research Grants - Young Investigators Grants
Duration: May 01, 2012 - April 30, 2016
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Dayane Batista Tada
Grantee:Dayane Batista Tada
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Assoc. researchers:Alisson Leonardo Matsuo ; Denise Costa Arruda ; Eudes Eterno Fileti ; Flávio Aimbire Soares de Carvalho ; Helena Couto Junqueira ; Luiz Rodolpho Raja Gabaglia Travassos ; Matheus Sacilotto de Moura ; Rosangela Itri ; Tatiane Moraes Arantes ; Tiago dos Santos Rodrigues
Associated scholarship(s):15/11281-6 - Studies of interactions between nanoparticles and biomolecules through surface plasmon resonance, BP.IC
14/17491-0 - Synthesis and functionalization of nanoparticles, BP.IC

Abstract

The present project aims at characterizing the cellular internalization of Nanoparticles (NPs). It has been demonstrated that NPs therapeutic efficiency and toxicity depend on their cytolocalization, which in turn, is defined by their internalization process. To study the interaction of NPs in biological systems, we will use a murine melanoma model system. The development of this project can provide useful information about NPs interaction with biomolecules, membrane and cells. NPs will be synthesized with different parameters in order to obtain high therapeutic efficiency and low toxicity.The use of NPs synthesis and NPs surface modification techniques in order to target a tumor cell and the controlled intracellular destination coupled with the understanding of chemical and biomolecular interactions between NPs and biological systems are important features of this project. Experiments proposed here may lead to the development of highly efficient NPs for melanoma therapy. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DUCATTI FORMAGGIO, DANIELA MARIA; DE OLIVEIRA NETO, XISTO ANTONIO; ALCANTARA RODRIGUES, LINA DAYSE; DE ANDRADE, VITOR MARTINS; NUNES, BRUNA C.; LOPES-FERREIRA, MONICA; FERREIRA, FABIANA G.; WACHESK, CRISTIANE C.; CAMARGO, EMERSON R.; CONCEICAO, KATIA; TADA, DAYANE BATISTA. In vivo toxicity and antimicrobial activity of AuPt bimetallic nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 21, n. 11 NOV 2019. Web of Science Citations: 0.
BRAGA, NATALIA F.; VITAL, DANIEL A.; GUERRINI, LILIA M.; LEMES, ANA P.; FORMAGGIO, DANIELA M. D.; TADA, DAYANE B.; ARANTES, TATIANE M.; CRISTOVAN, FERNANDO H. PHBV-TiO2 mats prepared by electrospinning technique: Physico-chemical properties and cytocompatibility. Biopolymers, v. 109, n. 5 MAY 2018. Web of Science Citations: 5.
DE MACEDO, ERENILDO FERREIRA; DUCATTI FORMAGGIO, DANIELA MARIA; SANTOS, NIVIA SALLES; TADA, DAYANE BATISTA. Gold Nanoparticles Used as Protein Scavengers Enhance Surface Plasmon Resonance Signal. SENSORS, v. 17, n. 12 DEC 2017. Web of Science Citations: 4.
ARRUDA, DENISE COSTA; DE OLIVEIRA, THAIS DOLZANY; FUKUDA CURSINO, PATRICIA HARUME; CARNEIRO MAIA, VERA SUSANA; BERZAGHI, RODRIGO; TRAVASSOS, LUIZ R.; TADA, DAYANE BATISTA. Inhibition of melanoma metastasis by dual-peptlde PLGA NPS. Biopolymers, v. 108, n. 5 SEP 2017. Web of Science Citations: 1.
TADA, DAYANE B.; BAPTISTA, MAURICIO S. Photosensitizing nanoparticles and the modulation of ROS generation. FRONTIERS IN CHEMISTRY, v. 3, MAY 27 2015. Web of Science Citations: 21.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.