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Clinical, immunological features and its correlation with genetic markers in canine visceral leishmaniasis

Grant number: 12/50285-9
Support type:Regular Research Grants
Duration: August 01, 2012 - January 31, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal researcher:Marcia Dalastra Laurenti
Grantee:Marcia Dalastra Laurenti
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. The disease affects mainly the cells of the Mononuclear Phagocitic System (MPS) in bone marrow, spleen, liver, lungs, intestine and skin and can be fatal if not treated. The incidence about 90% of VL cases is concentrated in five countries, including Brazil. Dogs are considered the main domestic reservoir of Leishmania (L.) infantum chagasi, constituting the main link in the chain of parasite transmission. In endemic areas, part of the dogs acquired the infection and develops disease immediately and part develops disease later and another part of the dogs never develop the disease. Generally, asymptomatic dogs exhibit resistance phenotype associated with the cellular immune response and high control of parasites, by the other side, symptomatic dogs exhibit phenotype of susceptibility associated with suppression of cellular immunity and exacerbation of the humoral immune response. Identification of genetic markers associated with different profiles of immune response can be useful for elucidation of the factors associated with maintenance of the asymptomatic infection or full manifestation of the disease in canine VL (CVL). Therefore, the aim of this study is to evaluate the cellular immune response and to identify genetic markers associated with different profiles of cellular immunity and clinical forms of CVL in dogs from São Paulo State. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANCHES, FRANCOISE P.; TOMOKANE, THAISE Y.; DA MATTA, VANIA L. R.; MARCONDES, MARY; CORBETT, CARLOS E. P.; LAURENTI, MARCIA D.. Expression of inducible nitric oxide synthase in macrophages inversely correlates with parasitism of lymphoid tissues in dogs with visceral leishmaniasis. ACTA VETERINARIA SCANDINAVICA, v. 56, . (12/50285-9)
BATISTA, LUIS F. S.; UTSUNOMIYA, YURI T.; SILVA, THAIS B. F.; DIAS, RAISSA A.; TOMOKANE, THAISE Y.; PACHECO, ACACIO D.; DA MATTA, VANIA L. R.; SILVEIRA, FERNANDO T.; MARCONDES, MARY; NUNES, CARIS M.; et al. Genome-Wide Association Study of Cell-Mediated Response in Dogs Naturally Infected by Leishmania infantum. Infection and Immunity, v. 84, n. 12, p. 3629-3637, . (12/50285-9, 12/05847-9, 14/01095-8)
LUÍS FÁBIO DA SILVA BATISTA; VÂNIA LÚCIA RIBEIRO DA MATTA; THAISE YUMIE TOMOKANE; ACÁCIO DUARTE PACHECO; FERNANDO TOBIAS SILVEIRA; CLAUDIO NAZARETIAN ROSSI; MARY MARCONDES; MÁRCIA DALASTRA LAURENTI. Canine antibody response to Lutzomyia longipalpis saliva in endemic area of visceral leishmaniasis.. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 3, p. 361-364, . (12/50285-9)
BATISTA, LUIS F. S.; TORRECILHA, RAFAELA B. P.; SILVA, RAFAELA B.; UTSUNOMIYA, YURI T.; SILVA, THAIS B. F.; TOMOKANE, THAISE Y.; PACHECO, ACACIO D.; BOSCO, ANELISE M.; PAULAN, SILVANA C.; ROSSI, CLAUDIO N.; et al. Chromosomal segments may explain the antibody response cooperation for canine leishmaniasis pathogenesis. Veterinary Parasitology, v. 288, . (12/05847-9, 14/01095-8, 12/50285-9)
BATISTA, LUIS F. S.; UTSUNOMIYA, YURI T.; SILVA, THAIS B. F.; CARNEIRO, MARIANA M.; PAIVA, JOYR S. F.; SILVA, RAFAELA B.; TOMOKANE, THAISE Y.; ROSSI, CLAUDIO N.; PACHECO, ACACIO D.; TORRECILHA, RAFAELA B. P.; et al. Canine leishmaniasis: Genome-wide analysis and antibody response to Lutzomyia longipalpis saliva. PLoS One, v. 13, n. 5, . (12/05847-9, 14/01095-8, 12/50285-9)
DA SILVA BATISTA, LUIS FABIO; RIBEIRO DA MATTA, VANIA LUCIA; TOMOKANE, THAISE YUMIE; PACHECO, ACCIO DUARTE; SILVEIRA, FERNANDO TOBIAS; ROSSI, CLAUDIO NAZARETIAN; MARCONDES, MARY; LAURENTI, MARCIA DALASTRA. Canine antibody response to Lutzomyia longipalpis saliva in endemic area of visceral leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 3, p. 361-364, . (12/50285-9)

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