Clinical, immunological evaluation and their correlation with genetic markers in canine visceral leishmaniasis

• Grant number: 12/05847-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2012
• End date: September 30, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Marcia Dalastra Laurenti
• Grantee: Luís Fábio da Silva Batista
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. The disease affects mainly the cells of the fagocitic mononuclear system in bone marrow, spleen, liver, lungs, intestine and skin and can be fatal if not be treated. The incidence of about 90% of cases of VL is concentrated in five countries, including Brazil. Dogs are considered the main domestic reservoir of Leishmania (L.) infantum chagasi, constituting the main link in the chain of transmission of the parasite. In endemic areas, a part of the dogs acquired the infection and develops disease immediately, another part develops disease later and another part never develop VL. Asymptomatic dogs exhibiting resistance phenotype associated with the cellular immune response and high control of parasites on the other hand, dogs exhibiting symptoms phenotype of susceptibility associated with suppression of cellular immunity and humoral immune response exacerbated. Identification of genetic markers associated with different profiles of immune response can be useful for elucidation of the factors associated with maintenance of the asymptomatic infection or full manifestation of the disease in canine VL. Therefore, the aim of this study is to evaluate the cellular immune response and to identify genetic markers associated with different profiles of cellular immunity and clinical forms of CVL in dogs from São Paulo State.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BATISTA, LUIS F. S.; UTSUNOMIYA, YURI T.; SILVA, THAIS B. F.; DIAS, RAISSA A.; TOMOKANE, THAISE Y.; PACHECO, ACACIO D.; DA MATTA, VANIA L. R.; SILVEIRA, FERNANDO T.; MARCONDES, MARY; NUNES, CARIS M.; et al. Genome-Wide Association Study of Cell-Mediated Response in Dogs Naturally Infected by Leishmania infantum. Infection and Immunity, v. 84, n. 12, p. 3629-3637, DEC 2016. (12/50285-9, 12/05847-9, 14/01095-8)

BATISTA, LUIS F. S.; TORRECILHA, RAFAELA B. P.; SILVA, RAFAELA B.; UTSUNOMIYA, YURI T.; SILVA, THAIS B. F.; TOMOKANE, THAISE Y.; PACHECO, ACACIO D.; BOSCO, ANELISE M.; PAULAN, SILVANA C.; ROSSI, CLAUDIO N.; et al. Chromosomal segments may explain the antibody response cooperation for canine leishmaniasis pathogenesis. Veterinary Parasitology, v. 288, DEC 2020. (12/05847-9, 14/01095-8, 12/50285-9)

BATISTA, LUIS F. S.; UTSUNOMIYA, YURI T.; SILVA, THAIS B. F.; CARNEIRO, MARIANA M.; PAIVA, JOYR S. F.; SILVA, RAFAELA B.; TOMOKANE, THAISE Y.; ROSSI, CLAUDIO N.; PACHECO, ACACIO D.; TORRECILHA, RAFAELA B. P.; et al. Canine leishmaniasis: Genome-wide analysis and antibody response to Lutzomyia longipalpis saliva. PLoS One, v. 13, n. 5, MAY 9 2018. (12/05847-9, 14/01095-8, 12/50285-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BATISTA, Luís Fábio da Silva. Identification of genetic markers associated to clinical, antibody and cellmediated reponses to natural Leishmania (Leishmania) infantum infection in dogs. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.