|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||September 01, 2012|
|Effective date (End):||September 30, 2015|
|Field of knowledge:||Agronomical Sciences - Veterinary Medicine - Animal Pathology|
|Principal researcher:||Marcia Dalastra Laurenti|
|Grantee:||Luís Fábio da Silva Batista|
|Home Institution:||Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. The disease affects mainly the cells of the fagocitic mononuclear system in bone marrow, spleen, liver, lungs, intestine and skin and can be fatal if not be treated. The incidence of about 90% of cases of VL is concentrated in five countries, including Brazil. Dogs are considered the main domestic reservoir of Leishmania (L.) infantum chagasi, constituting the main link in the chain of transmission of the parasite. In endemic areas, a part of the dogs acquired the infection and develops disease immediately, another part develops disease later and another part never develop VL. Asymptomatic dogs exhibiting resistance phenotype associated with the cellular immune response and high control of parasites on the other hand, dogs exhibiting symptoms phenotype of susceptibility associated with suppression of cellular immunity and humoral immune response exacerbated. Identification of genetic markers associated with different profiles of immune response can be useful for elucidation of the factors associated with maintenance of the asymptomatic infection or full manifestation of the disease in canine VL. Therefore, the aim of this study is to evaluate the cellular immune response and to identify genetic markers associated with different profiles of cellular immunity and clinical forms of CVL in dogs from São Paulo State.