Preparation, in vitro characterization and in vivo evaluation of mucoadhesive polymer films in the prevention and treatment of acute oral mucositis induced by chemotherapy and radiotherapy

• Grant number: 11/21219-5
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2012
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marco Vinícius Chaud
• Grantee: Marco Vinícius Chaud
• Host Institution: Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil
• Associated researchers: Daiane Tenor Lopes ; Gilson Luchezi Delgado ; Luis Antonio Pires ; Maria Helena Andrade Santana ; Maricene Sabha ; Patricia Severino ; Perla Porto Leite Shitara

Abstract

Oral mucositis is a co-morbidity that affects patients on antineoplasic treatment of head and neck. This disease is characterized by pain and ulceration of the mucosa and aggravates the course of treatment with chemotherapy or radiation, affecting the nutritional status of patients and interrupt cycles of anticancer treatments. The available treatments for oral mucositis are palliative and include local anesthesia, decontamination, cryotherapy and anti-inflammatory. The objective of this work is the technological development of hydrogels, in the form of particles and films mucoadhesives and drug controlled release. The hydrogels will be prepared with composition based on hyaluronic acid and other polymers compatible with the extracellular membrane. The drugs used are commonly used in dental products. The hydrogels are physically and chemically characterized and evaluated in vivo. This study opens the possibility of improving the quality of life of patients on anticancer treatment; carry out the protocols radiotherapy and chemotherapy, decrease treatment time and the risk of co-morbidity accompanying radiotherapy and chemotherapy. This study opens the possibility for further investigation of therapeutic products to prevent and treat others as mucositis of the pharynx and the vaginal cavity (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YOSHIDA, VALQUIRIA M. H.; BALCAO, VICTOR M.; VILA, MARTA M. D. C.; OLIVEIRA JUNIOR, JOSE M.; ARANHA, NORBERTO; CHAUD, MARCO V.; GREMIAO, MARIA P. D.. Zidovudine-Poly(L-Lactic Acid) Solid Dispersions with Improved Intestinal Permeability Prepared by Supercritical Antisolvent Process. Journal of Pharmaceutical Sciences, v. 104, n. 5, p. 1691-1700, MAY 2015. (11/21219-5, 12/01333-0)

GALVAO ALMEIDA, NILSA MARIA; LIMA, RENATA; RIBEIRO ALVES, THAIS FRANCINE; REBELO, MARCIA DE ARAUJO; SEVERINO, PATRICIA; CHAUD, MARCO VINICIUS. A novel dosage form for buccal administration of bupropion. Brazilian Journal of Pharmaceutical Sciences, v. 51, n. 1, p. 91-100, JAN-MAR 2015. (11/21219-5)

AMARAL, VENANCIO ALVES; RIBEIRO ALVES, THAIS FRANCINE; DE SOUZA, JULIANA FERREIRA; BATAIN, FERNANDO; DE MOURA CRESCENCIO, KESSI MARIE; SOEIRO, VICTORIA SOARES; DE BARROS, CECILIA TORQUETI; CHAUD, MARCO VINICIUS. Phenolic Compounds from Psidium guajava (Linn.) Leaves: Effect of the Extraction-Assisted Method Upon Total Phenolics Content and Antioxidant Activity. BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, v. 11, n. 2, p. 12-pg., 2021-04-15. (18/13432-0, 11/21219-5)

ALVES, THAIS F. R.; RIOS, ALESSSANDRA C.; PONTES, KATIUSCA DA SILVA; PORTELLA, DECIO L.; ARANHA, NORBERTO; SEVERINO, PATRICIA; SOUTO, ELIANA B.; GONSALVES, JOYCE K. M.; NUNES, ROGERIA DE SOUZA; CHAUD, V, MARCO. Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case. PHARMACEUTICS, v. 12, n. 7, JUL 2020. (11/21219-5, 18/13432-0, 18/11350-6)