| Grant number: | 11/21954-7 |
| Support Opportunities: | Regular Research Grants |
| Start date: | August 01, 2012 |
| End date: | July 31, 2014 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Physical-Chemistry |
| Principal Investigator: | Mateus Borba Cardoso |
| Grantee: | Mateus Borba Cardoso |
| Host Institution: | Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
| Associated researchers: | Heberton Wender Luiz dos Santos ; Jörg Kobarg ; Juliana Martins de Souza e Silva ; Kaliandra de Almeida Gonçalves ; Luciane França de Oliveira |
Abstract
The project described here aims to functionalize the surface of two distinct types of composites: silica-antitumor drug and silver-silica composites. The aim is to improve performance and biomedical compatibility of these structures. The silica-antitumor drug composites will be functionalized with folate seeking to obtain a target specific structure, thus it is expected that this will be preferentially endocytosed by tumor cells. Nanoparticles will be characterized in every step of functionalization and delivery tests will be done by using tumoral and normal cells. Silver-silica core-shell nanoparticles will be functionalized with beta-lactam antibiotics. Thus, the composite formed possibly will present dual bactericidal activity arising from the synergy between silver and beta-lactam agent. The composites will be characterized in each step of the synthesis process and inhibition tests with resistant and non-resistant bacteria will be performed. In both systems (silica-antitumor drug and silver-silica), it is intended to initially cover the nanoparticles with 3-aminopropiltrietoxissilano (APTES), obtaining amino groups on the surface of the nanoparticle. Thereafter, the amino groups will react with the carboxyl groups of the molecule of interest, via coupling reaction, so that they will be linked to the nanoparticle.Moreover, through this proposal is expected to consolidate the young complex materials research group at LNLS. The subject of the proposed research will develop areas of synthesis, functionalization, characterization and applications of functionalized complex systems dedicated to nanomedicine. This is of extreme importance for the country taking into account the shortage of researchers working on the proposed theme in the national territory. (AU)
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