Immunoregulatory function of HLA-G molecules in multiple sclerosis and experimental autoimmune encephalomyelitis

• Grant number: 12/04565-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2012
• End date: December 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Leonilda Maria Barbosa dos Santos
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The HLA-G molecules either express on cell surface or in the soluble form play an important role in the induction of immunological tolerance.These molecules are express in various cells type and their involvement in the generation of regulatory T lymphocytes was previously described. The aim of this study is to understand the immunoregulatory function of HLA-G express on plasmacytoid dendritic cells in patients with multiple sclerosis and if the neuron express HLA-G in different phases of EAE. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMILO, DANIELA S.; PRADELLA, FERNANDO; PAULINO, MARIA FERNANDA; BARACAT, EMILIO C. E.; MARINI, SOFIA H.; GUERRA, JR., GIL; PAVIN, ELIZABETH J.; PARISI, CANDIDA; LONGHINI, ANA LEDA F.; MARQUES, SILVIA B.; et al. Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies. PEDIATRIC DIABETES, v. 21, n. 4, p. 606-614, JUN 2020. (12/24667-1, 16/17404-5, 13/12109-7, 12/04565-0)

VON GLEHN, FELIPE; JARIUS, SVEN; CAVALCANTI LIRA, RODRIGO PESSOA; ALVES FERREIRA, MARIA CAROLINA; RIBEIRO VON GLEHN, FADUA H.; COSTA E CASTRO, STELLA MARIS; BELTRAMINI, GUILHERME COCO; BERGO, FELIPE P. G.; FARIAS, ALESSANDRO S.; BRANDAO, CARLOS OTAVIO; et al. Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders. MULTIPLE SCLEROSIS, v. 20, n. 9, p. 1189-1197, AUG 2014. (12/04565-0, 11/18728-5)

DIAS-CARNEIRO, RAFAEL P. C.; VON GLEHN, FELIPE; MORAES, ADRIEL S.; BOLDRINI, VINICIUS O.; DAMASCENO, ALFREDO; ANDRADE, MARILIA D.; LIMA, ALLINY C. D.; CASANOVA, CRISTIANE S.; TILBERY, CHARLES P.; DAMASCENO, BENITO P.; et al. MRZH reaction increases sensitivity for intrathecal IgG synthesis in IgG Oligoclonal band negative Multiple Sclerosis patients. Journal of Neuroimmunology, v. 300, p. 30-35, NOV 15 2016. (12/04565-0)

MORAES, ADRIEL S.; PAULA, ROSEMEIRE F. O.; PRADELLA, FERNANDO; SANTOS, MARIANA P. A.; OLIVEIRA, ELAINE C.; VON GLEHN, FELIPE; CAMILO, DANIELA S.; CERAGIOLI, HELDER; PETERLEVITZ, ALFREDO; BARANAUSKAS, VITOR; et al. The Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells Induced by Multiwalled Carbon Nanotubes Reduces the Severity of Experimental Autoimmune Encephalomyelitis. CNS Neuroscience & Therapeutics, v. 19, n. 9, p. 682-687, SEP 2013. (12/04565-0, 11/18728-5, 11/15175-5, 11/15639-1, 12/09879-2, 12/01408-0)