Canine visceral leishmaniasis: abdominal imaging study of the appendicular skeleton in dogs naturally infected

• Grant number: 12/02484-2
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2012
• End date: September 30, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Maria Jaqueline Mamprim de Arruda Monteiro
• Grantee: Maria Jaqueline Mamprim de Arruda Monteiro
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Leishmaniasis is a cosmopolitan disease of zoonotic potential, which affects humans and a variety of domestic and wild animals, with different clinical presentations. Caused by protozoa of the genus Leishmania spp., And is the etiologic agent in Brazil as Leishmania (Leishmania) chagasi. In the Brazilian federation, the importance of visceral leishmaniasis, is its high incidence and geographical distribution. What makes the domestic environment, dogs and hosts important sources of infection for the vectors for the high infectivity. Dogs infected are considered more epidemiologically important disease in humans for several reasons: high prevalence, incidence and primary enzootic large contingent of parasitism in the skin. The clinical diagnosis is still a challenge for health profissinais because of the wide variety of signs and symptoms as well as the high percentage of asymptomatic animals. However, affected animals usually develop a chronic systemic disease may present nonspecific clinical and varied. The analysis associated with imaging (ultrasound, digital radiography and computed tomography) of dogs with visceral leishmaniasis assists in the investigation of disease, however, reports in the literature are scarce and often controversial. Given the importance of visceral leishmaniasis in public health because the disease has become an emerging state of São Paulo, this project aims to evaluate the contribution of different modes of diagnostic imaging in dogs naturally affected by visceral leishmaniasis. The digital radiographic and tomographic analysis of the appendicular skeleton is comparative and represents the continuity of the research developed in the master's scholarship in order to investigate the detection of lesions of the disease early. Report the possible changes abdominal ultrasound found in these animals as a contribution to diagnosis, it is not yet in the veterinary literature citations. The study aims to provide subsidies for the diagnosis of clinical disease for veterinarians who work in areas endemic for the disease in dogs and humans. To do so, will be used 50 dogs naturally infected with serologic or parasitologic positive for Leishmania spp., Referred to the Veterinary Hospital of Universidade Paulista, the city of Bauru, São Paulo, during the period from March 2012 to March 2013. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELOTTA, ALEXANDRA F.; GOMES, MARCELA C.; ROCHA, NOEME S.; MELCHERT, ALESSANDRA; GIUFFRIDA, ROGERIO; SILVA, JEANA P.; MAMPRIM, MARIA J.. Sonography and sonoelastography in the detection of malignancy in superficial lymph nodes of dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, v. 33, n. 3, p. 1403-1413, MAY 2019. (12/02484-2)

SILVA, ALEXANDRE REDSON S.; OLIVEIRA, HUGO S.; GOMES, ANA AMELIA D.; BESERRA, HUGO ENRIQUE O.; SILVA, JEANA P.; SANTOS-DONI, THAIS R.; TSUNEMI, MIRIAM H.; MARCONDES, MARY; RAHAL, SHEILA C.; MAMPRIM, MARIA J.. Joint involvement in canine visceral leishmaniasis: Orthopedic physical examination, radiographic and computed tomographic findings. Veterinary Parasitology, v. 299, NOV 2021. (12/02484-2, 12/01526-3, 18/21048-5)