Expression of teneurins (TEN) and teneurins C-terminal associated peptides (TCAP) in the central nervous system of non-human primates (Cebus apella)

• Grant number: 12/03067-6
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2012
• End date: August 31, 2015
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Cláudio Aparecido Casatti
• Grantee: Cláudio Aparecido Casatti
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Teneurins (TENs) represent transmembrane type II proteins highly conserved among the species and mainly expressed in the central nervous system (CNS). This family is constituted by four homologues named as teneurins 1-4 in vertebrates. These proteins exert an important role in the neuronal interaction, besides a possible regulatory activity in gene transcription. Previous studies determined that the terminal exon of each teneurin has a genomic sequence able to translate a peptide exhibiting high homology to corticotrophin-releasing factor (CRF). These peptides were named as c-terminal associated peptides (TCAP1-4), exerting significant modulatory activity in behavior disorders linked to stress. Studies focusing TENs and TCAPs have been of large interest, in view of the possible therapeutic applications of these peptides. However, basic information on these new peptidergic systems, such as their neuroanatomical distribution in the primate brain needs to be elucidated, in order to support their physiological findings and pharmacological use. Consequently, the present study aims to evaluate the detailed distribution of neurons exhibiting immunoreactivity to TENs1-4 and TCAPs1-4 in the non-human primate brain (Cebus apella) using immunohistochemistry and in situ hybridization methods. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ERVOLINO, EDILSON; STATKIEVICZ, CRISTIAN; TORO, LUAN FELIPE; DE MELLO-NETO, JOAO MARTINS; CAVAZANA, THAMIRES PRISCILA; MARDEGAN ISSA, JOAO PAULO; MENEGATI DORNELLES, RITA CASSIA; DE ALMEIDA, JULIANO MILANEZI; HITOMI NAGATA, MARIA JOSE; OKAMOTO, ROBERTA; et al. Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate. BONE, v. 120, p. 101-113, MAR 2019. (13/25367-4, 12/03067-6, 13/26779-4, 14/02199-1, 15/22395-2)

TORRES-DA-SILVALI, K. R.; TESSARIN, G. W. L.; DIAS, C. A.; GUIATI, I. Z.; ERVOLINO, E.; GONCALVES, A.; BENETI, I. M.; LOVEJOY, D. A.; CASATTI, C. A.. Teneurin-2 presence in rat and human odontoblasts. PLoS One, v. 12, n. 9, SEP 19 2017. (12/08833-9, 12/03067-6, 13/01288-8)

STATKIEVICZ, CRISTIAN; TORO, LUAN FELIPE; DE MELLO-NETO, JOAO MARTINS; DE SA, DANIELA PEREIRA; CASATTI, CLAUDIO APARECIDO; MARDEGAN ISSA, JOAO PAULO; ANGELO CINTRA, LUCIANO TAVARES; DE ALMEIDA, JULIANO MILANEZI; HITOMI NAGATA, MARIA JOSE; GARCIA, VALDIR GOUVEIA; et al. Photomodulation multiple sessions as a promising preventive therapy for medication-related osteonecrosis of the jaws after tooth extraction in rats. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 184, p. 7-17, JUL 2018. (13/26779-4, 12/03067-6, 14/02199-1, 14/14118-6)

TORRES-DA-SILVA, K. R.; DA SILVA, A. V.; BARIONI, N. O.; TESSARIN, G. W. L.; DE OLIVEIRA, J. A.; ERVOLINO, E.; HORTA-JUNIOR, J. A. C.; CASATTI, C. A.. Neurochemistry study of spinal cord in non-human primate (Sapajus spp.). EUROPEAN JOURNAL OF HISTOCHEMISTRY, v. 60, n. 3, p. 175-182, 2016. (12/08833-9, 12/03067-6, 13/25737-6, 08/02771-6)

BATTAGELLO, DANIELLA S.; DINIZ, GIOVANNE B.; CANDIDO, PAULO L.; DA SILVA, JOELCIMAR M.; DE OLIVEIRA, AMANDA R.; DA SILVA, KELLY R. TORRES; LOTFI, CLAUDIMARA F. P.; DE OLIVEIRA, JOSE A.; SITA, LUCIANE V.; CASATTI, CLAUDIO A.; et al. Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]. FRONTIERS IN NEUROANATOMY, v. 11, JUL 24 2017. (12/08833-9, 12/03067-6, 16/02224-1, 16/02748-0, 04/13849-5, 11/09816-8, 09/06769-9)

CRUZ-RIZZOLO, ROELF J.; LIMIERI, LAIS LEAL; DE PAIVA, ISABELA ROGERIO; BARBOSA RIBEIRO, JESSICA O.; PIMENTA, TAIS FERNANDES; PINATO, LUCIANA; ERVOLINO, EDILSON; CASATTI, CLAUDIO APARECIDO; GUISSONI CAMPOS, LEILA M.; LIBERTI, EDSON APARECIDO. Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats. IBRO REPORTS, v. 3, p. 7-pg., 2017-12-01. (12/03067-6, 12/13433-0, 12/11307-7)