Effects of aerobic exercise on pulmonary fibrosis induced by bleomycin

• Grant number: 12/51464-4
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2013
• End date: January 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: BAYLAT/StMBW - Bavarian Academic Center for Latin America and Bavarian State Ministry of Science and the Arts
• Principal Investigator: Rodolfo de Paula Vieira
• Grantee: Rodolfo de Paula Vieira
• Principal researcher abroad: Oliver Eickelberg
• Institution abroad: Ludwig Maximilian University of Munich (LMU Munich), Germany
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil

Abstract

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognostic and no effective treatment is available. Although there are a considerable number of studies showing that pulmonary rehabilitation programs for IPF patients result in proved quality of life and disease management, the possible mechanisms involved in this beneficial effects remain to be elucidated. In this context, aerobic exercise has demonstrated to reduce inflammation and remodeling in expermental models of asthma, COPD and acute lung injury. Preliminary results show that aerobic exercise was effective to reduce lung inflammation in a model of pulmonary fibrosis induced by bleomycin. Therefore, the present study aims to evaluate the effects of treadmill aerobic exercise training in lung inflammation, structure and function in a chronic model of bleomycin-induced pulmonary fibrosis... (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRADE-SOUSA, ADILSON SANTOS; PEREIRA, PAULO ROGERIO; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; PEREIRA VELOSA, ANA PAULA; TEODORO, WALCY ROSOLIA; et al. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One, v. 11, n. 9, SEP 27 2016. (12/15165-2, 14/14604-8, 14/23196-0, 12/51464-4)

PEREIRA, PAULO ROGERIO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; DAVINO CHIOVATTO, JAIME EDUARDO; MATOS, YVES; GREIFFO, FLAVIA REGINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRUGEMMAN, THAYSE REGINA; DELLE, HUMBERTO; IDZKO, MARCO; et al. Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 7, p. 1276-1284, JUL 2016. (12/15165-2, 14/23196-0, 14/14604-8, 12/51464-4)

EL-MAFARJEH, ELIAS; MARTINS, GISELE HENRIQUE CARDOSO; PROBST, JESSICA JORGE; SANTOS-DIAS, ALANA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE BARROS, MARCELO PAES; DE OLIVEIRA, LUIS VICENTE FRANCO; DE ANDRADE, LEANDRO DAMAS; DA PALMA, RENATA KELLY; MORAES-FERREIRA, RENILSON; et al. Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, OCT 17 2020. (19/14115-0, 17/06032-2, 14/14604-8, 16/04845-3, 12/51464-4, 15/20562-9, 12/15165-2, 19/11008-9)