| Grant number: | 12/23651-4 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2013 |
| End date: | February 28, 2015 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry |
| Principal Investigator: | Douglas Wagner Franco |
| Grantee: | Douglas Wagner Franco |
| Host Institution: | Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
| City of the host institution: | São Carlos |
Abstract
The present research project presents a natural extension of previous ones including HNO/NO- system. The reactivity aspects still enclosed in the present project. The knowledge regarding to the reactivity changes on the phosphorus esters coordinated to ruthenium can provide a better understanding of its reactivity and help on tailoring more robust compounds with respect to nucleophilic attack enabling its application as metallopharmaceutical platform. Similarly, the reactions between the nitrosyl complex and the RSH / RSSR system will help to better understand the activation aspects of these compounds in biological medium and the reactivity of these molecules. Indeed, this proposition is not limited to fundamental aspects, but also exhibit implications on the metallodrugs development area. The ligand activation through coordination, already successfully tested with the benznidazole, observing an increase on the activity due to a facilitation of its reduction will now be extended to nitrocompounds. In this case, however, it is desired a decrease on the reducing potential of the ligand inducing selectivity and reducing the toxicity. With respect to the HNO/NO- system, efforts will be directed towards developing the fundamental chemistry using a similar approach used for the nitrosyl systems. (AU)
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