Evaluation of colonization and infection by multiresistant bacteria in patients with chronic kidney disease

• Grant number: 12/07671-5
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2013
• End date: October 31, 2015
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Dulce Aparecida Barbosa
• Grantee: Dulce Aparecida Barbosa
• Host Institution: Escola Paulista de Enfermagem (EPE). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Antonio Carlos Campos Pignatari

Abstract

Infection is a major cause of morbidity and the second most frequent cause of mortality in patients with failure chronic renal disease. The S. aureus, coagulase negative Staphylococcus and Enterococcus spp are the main agents colonizing and causing infections in this population, as well as producing Klebsiella pneumoniae carbapenemase (KPC). Considering the possibility of concomitant infection and colonization by S. aureus methilicin resistance (MRSA), S. aureus with intermediate resistance to vancomycin (VISA), vancomycin-resistant Enterococcus (VRE) and KPC, we are motivated in this study. Objectives: i) determine the prevalence of colonization or infection, morbidity and mortality, ii) identify the risk factors, iii) to analyze the mode of dissemination and cross transmission -iv) determine the prevalence of resistance genes. Method: a cohort study in the Department of Dialysis and Transplantation of Unifesp which will be included 900 patients (conservative treatment, dialysis and transplantation). To determine the prevalence of colonization will be conducted surveillance of microorganisms: MRSA and VISA: through collection of nasal samples from all patients. Surveillance of VRE and KPC: through stool samples or rectal swab. Patients will be followed by a period of six months to record the morbid complications such as infection and causes of hospitalization and death. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REZENDE, T. F. T.; DOI, A. M.; QUILES, M. G.; PIGNATARI, A. C. C.; MANFRENDI, S.; GROTHE, C.; TAMINATO, M.; BARBOSA, D. A.. Detection of colonization by carbapenem-resistant organisms by real-time polymerase chain reaction from rectal swabs in patients with chronic renal disease. Journal of Hospital Infection, v. 96, n. 2, p. 123-128, JUN 2017. (12/07671-5)