Biocatalysis: the use of plant cells and lipases in organic synthesis - application on asymmetric synthesis of biologically active compounds

• Grant number: 09/00617-2
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: September 01, 2009
• End date: August 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Alvaro Takeo Omori
• Grantee: Alvaro Takeo Omori
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated scholarship(s): 13/18700-9 - Synthesis of substituted 7-azanorbornanes by intramolecular mannich reaction: application to asymmetric synthesis of epibatidine, BP.MS

Abstract

This proposal aims to initiate a research group in Organic Synthesis and Biocatalysis at Centro de Ciências Naturais e Humanas of ABC Federal University. The research field is focused on application of enantiomerically pure compounds obtained from biocatalytic methods in organic synthesis of biologically active compounds. The biocatalytic methods to be applied include the use of vegetables in different substrates and the use of lipases in enzymatic resolution of alcohols and amines. Some of these intermediates would be used in the Oseltamivir, Gabaculine and Epibatidine synthesis.This proposal aims to initiate a research group in Organic Synthesis and Biocatalysis at Centro de Ciências Naturais e Humanas of ABC Federal University. The research field is focused on application of enantiomerically pure compounds obtained from biocatalytic methods in organic synthesis of biologically active compounds. The biocatalytic methods to be applied include the use of vegetables in different substrates and the use of lipases in enzymatic resolution of alcohols and amines. Some of these intermediates would be used in the Oseltamivir, Gabaculine and Epibatidine synthesis. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, EDGARD A.; RODEZNO, SINDY V. A.; OMORI, ALVARO T.; CUNHA, RODRIGO L. O. R.. A study on the enzyme catalysed enantioselective hydrolysis of methyl 2-methyl-4-oxopentanoate, a precursor of chiral gamma-butyrolactones. BIOCATALYSIS AND BIOTRANSFORMATION, v. 37, n. 2, p. 115-123, MAR 4 2019. (09/00617-2)

CUNHA, RODRIGO L. O. R.; FERREIRA, EDGARD A.; OLIVEIRA, CAMILA S.; OMORI, ALVARO T.. Biocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?. BIOTECHNOLOGY ADVANCES, v. 33, n. 5, SI, p. 614-623, SEP-OCT 2015. (09/00617-2)

OMORI, ALVARO TAKEO; LOBO, FLAVIA GONCALVES; GONCALVES DO AMARAL, ANNA CAROLINA; DE OLIVEIRA, CAMILA DE SOUZA. Purple carrots: Better biocatalysts for the enantioselective reduction of acetophenones than common orange carrots (D. carota). JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v. 127, p. 93-97, MAY 2016. (09/00617-2, 14/25659-8)

DE OLIVEIRA FILHO, RONALDO E.; OMORI, ALVARO T.. Recent Syntheses of Frog Alkaloid Epibatidine. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 837-850, MAY 2015. (09/00617-2, 13/18700-9)

CUNHA, RODRIGO L. O. R.; FERREIRA, EDGARD A.; OLIVEIRA, CAMILA S.; OMORI, ALVARO T.. Biocatalysis for desymmetrization and resolution of stereocenters beyond the reactive center: How far is far enough?. BIOTECHNOLOGY ADVANCES, v. 33, n. 5, p. 10-pg., 2015-09-01. (09/00617-2)