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Oxindole alkaloids from Uncaria tomentosa: biosynthetic studies and alkaloids analogues obtained by precursor-directed biosynthesis

Grant number: 13/07349-9
Support type:Research Grants - Young Investigators Grants
Duration: January 01, 2014 - December 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Adriana Aparecida Lopes
Grantee:Adriana Aparecida Lopes
Home Institution: Universidade de Ribeirão Preto (UNAERP). Campus Ribeirão Preto. Ribeirão Preto , SP, Brazil
Assoc. researchers:Ana Maria Soares Pereira ; Maysa Furlan ; Norberto Peporine Lopes ; Suzelei de Castro França
Associated grant(s):16/50463-5 - Exclusive production of fluoro-unnatural oxindole alkaloids by transgenic Uncaria guianensis via precursor-directed biosynthesis, AP.R SPRINT
15/26066-3 - Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging, PUB.ART
Associated scholarship(s):18/17324-7 - Obtaining new benzofuran-derived alkaloids using precursor-directed biosynthesis in Uncaria tomentosa, BP.IC
17/04645-7 - Production of methylated oxindole alkaloids analogues by precursor-directed biosynthesis using Uncaria tomentosa species, BP.IC
16/18799-3 - Chemical and molecular (cDNA - SRAP) approaches from precursor-directed biosynthesis experiments in Uncaria guianensis, BP.IC
+ associated scholarships 15/18978-2 - Production of methylated oxindole alkaloid analogues by precursor-directed biosynthesis using in vitro Uncaria guianensis, BP.IC
15/18339-0 - Fluorinated analogues of pentacyclic oxindole alkaloids optimization production by precursor-directed biosynthesis using Uncaria guianensis in vitro, BP.IC
13/22609-7 - Oxindole alkaloids from Uncaria tomentosa: biosynthetic studies and alkaloids analogues obtained by precursor-directed biosynthesis, BP.JP - associated scholarships

Abstract

Natural products and their derivatives represent one of the successful alternatives in the discovery of new drugs. Among some of the main approaches to diversify the structure of a natural product are the semi-synthesis and the biotransformation. Another way to diversify the biosynthesis of natural products is related to direct or indirect modifications in the organism, through the addition of unnatural precursors in the culture medium, called precursor-directed biosynthesis. This research project considers the use of precursor-directed biosynthesis to obtain oxindole alkaloids analogues that display important anti-tumoral properties, using "in vitro" micropropagation of Uncaria tomentosa (Rubiaceae). The vegetal culture medium will be supplemented with different tryptophan analogues, the important indolic precursor of the biosynthetic route of pentaciclic oxindole alkaloids (AOP). Information about AOP biosynthesis is essential for the knowledge of the involved biosynthetic pathways. This way, studies using enriched precursors, in case 1-13C-D-glucose, are important for the knowledge of the biosynthetic pathways, specially the terpenoid pathway that can occur by mevalonate (MVA) and/or 1-deoxy-D-xylulose 5-phosphate pathways (MEP). All oxindole alkaloids analogues obtained by precursor-directed biosynthesis, as well as the natural alkaloids, will be submitted to the evaluation of anti-tumoral and anti-inflammatory activities. Therefore, this project aims to implement a new interdisciplinary research field in Biosynthesis in the Departamento de Biotecnologia Vegetal da Universidade de Ribeirão Preto (UNAERP). The consolidation of this proposal must be achieved by using precursor-directed biosynthesis in order to obtain oxindolic alkaloids analogues from Uncaria tomentosa, which will be evaluated in anti-tumoral and anti-inflammatory assays aiming to widen the therapeutic options. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Study aims at boosting antitumoral activity of compound extracted from an Amazon plant 
Study aims at boosting antitumoral activity of compound extracted from an Amazon plant 
Articles published in other media outlets (32 total):
More itemsLess items
EBC Rádios: Pesquisa aponta potencial da planta unha-de-gato para tratar tumores (26/Nov/2019)
Plantão News (MT): Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (25/Nov/2019)
Revista Ecológico online: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (20/Nov/2019)
Sou Ecológico: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (20/Nov/2019)
Projeto Colabora: Planta amazônica contra tumores (16/Nov/2019)
Diário da Saúde: Planta amazônica tem efeitos antitumorais multiplicados em laboratório (11/Nov/2019)
Confap - Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa: Estudo busca potencializar ação, contra tumores, de composto extraído de planta amazônica (11/Nov/2019)
Saúde Curiosa: "Unha-de-gato": Planta amazônica pode agir contra tumor! (11/Nov/2019)
Hypeness: Planta amazônica que pode agir contra tumor está sendo estudada por cientistas brasileiros (11/Nov/2019)
Espaço Ecológico no Ar: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (08/Nov/2019)
LabNetwork: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (08/Nov/2019)
Gestão Ambiental: Estudo de Pesquisadores de Ribeirão Preto e de São Carlos busca potencializar ação contra tumores de composto extraído de planta amazônica (08/Nov/2019)
Brasil CT&I: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (08/Nov/2019)
Jornal da Ciência online: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
TNH1: Cientistas buscam aumentar ação anti-inflamatória da planta amazônica unha-de-gato (07/Nov/2019)
Atemporal: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Sociedade Científica: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Pharma Innovation: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Portal Neo Mondo: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Comunicação Popular e Comunitária na Amazônia: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Portal da Enfermagem: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
Jornal Integração: Estudo busca potencializar ação contra tumores de composto extraído de planta amazônica (07/Nov/2019)
NCYT Amazings (Espanha): En busca de potenciar la acción antitumoral de un compuesto extraído de una planta amazónica (05/Nov/2019)
Phys.Org (Reino Unido): Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (01/Nov/2019)
Global Health News Wire (EUA): Study Aims at Boosting Antitumoral Activity of Compound Extracted from an Amazon Plant (01/Nov/2019)
News Medical (Austrália): Increasing anti-tumor activity of compound extracted from an Amazon plant (31/Oct/2019)
Science Codex: Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (31/Oct/2019)
Confederación Farmacéutica Argentina (Argentina): Científicos brasileños buscan potenciar la acción antitumoral de un compuesto extraído de una planta amazónica (31/Oct/2019)
Scienmag Science Magazine (Reino Unido): Study Aims At Boosting Antitumoral Activity Of Compound Extracted From An Amazon Plant (31/Oct/2019)
Brightsurf: Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (31/Oct/2019)
7thSpace: Study aims at boosting antitumoral activity of compound extracted from an Amazon plant (31/Oct/2019)
Biotech News (Austrália): Increasing anti-tumor activity of compound extracted from an Amazon plant (31/Oct/2019)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES, ADRIANA A.; CHIOCA, BIANCA; MUSQUIARI, BRUNO; CREVELIN, EDUARDO J.; FRANCA, SUZELEI DE C.; FERNANDES DA SILVA, MARIA FATIMA DAS G.; PEREIRA, ANA MARIA S. Unnatural spirocyclic oxindole alkaloids biosynthesis in Uncaria guianensis. SCIENTIFIC REPORTS, v. 9, AUG 5 2019. Web of Science Citations: 0.
PINA, EDIEIDIA S.; SILVA, DENISE B.; TEIXEIRA, SIMONE P.; COPPEDE, JULIANA S.; FURLAN, MAYSA; FRANCA, SUZELEI C.; LOPES, NORBERTO P.; PEREIRA, ANA MARIA S.; LOPES, ADRIANA A. Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. SCIENTIFIC REPORTS, v. 6, MAR 4 2016. Web of Science Citations: 6.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.