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Evaluation of temporomandibular joint in patients with severe hemophilia: clinical aspects and application of T2 relaxometry in magnetic resonance imaging

Grant number: 13/10999-5
Support type:Regular Research Grants
Duration: December 01, 2013 - November 30, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:André Luiz Ferreira Costa
Grantee:André Luiz Ferreira Costa
Home Institution: Pró-Reitoria de Pós-Graduação, Pesquisa e Extensão. Universidade Cidade de São Paulo (UNICID). São Paulo , SP, Brazil
Assoc. researchers:Clarissa Lin Yasuda ; Claudio Fróes de Freitas ; Maria Elvira Pizzigatti Correa ; Rívea Inês Ferreira ; Sara Teresinha Olalla Saad


Haemophilia is a hereditary blood-coagulation disorder that is characterized by sporadic bleeding manifestations that occur mostly in the form of hematomas and hemarthrosis, which represents one of the most typical manifestations of this disease. Hemarthrosis can produce chronic degenerative changes in the affected joint with deposition of iron from hemoglobin, causing the destruction of cartilage and bone of joints. Little is known about the involvement of the temporomandibular joint (TMJ) in patients with hemophilia with rare cases reported in the literature. We propose to a clinical assessment the TMJs of severe hemophilic patients and use and MR imaging and apply relaxometry to quantify the abnormalities magnetic relaxation in T2-weighted images, small changes in cartilage and identification of iron tissue. This project will contribute for a better understanding of the action mechanisms of hemarthrosis, and can support in more specific therapeutic and appropriate treatment in hemophilic arthropathy. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBIERI, ANA AMELIA; FERREIRA COSTA, ANDRE LUIZ; PEREZ GOMES, JOAO PEDRO; FRANCO RICARDO, ANA LUCIA; BRAZ-SILVA, PAULO HENRIQUE; PEREIRA DE CASTRO LOPES, SERGIO LUCIO. Association of volume and voxel intensity of the articular disc and lateral pterygoid muscle in migraine patients: a study with magnetic resonance imaging. ACTA ODONTOLOGICA SCANDINAVICA, OCT 2019. Web of Science Citations: 0.
STREVA, ALESSANDRA MOTTA; RAPHAELLI NAHAS-SCOCATE, ANA CARLA; PEREIRA DE CASTRO LOPES, SERGIO LUCIO; FERREIRA COSTA, ANDRE LUIZ. MRI as a method of evaluation and predicting mandibular growth based on temporomandibular joint. PEDIATRIC DENTAL JOURNAL, v. 29, n. 2, p. 97-104, AUG 2019. Web of Science Citations: 0.

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