Evaluation of the obliteration and conductance hydraulic of the dentine tubules using sodium trimetaphosphate toothpaste: in vitro study

• Grant number: 13/25531-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2014
• End date: June 30, 2016
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Denise Pedrini
• Grantee: Denise Pedrini
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The aim is analyze the in vitro action of TMP (conventional or nanoparticulate) associated with fluoride (F) toothpaste formulations in the obliteration of dentinal tubules and hydraulic conductance. Dentin blocks (4x4x2 mm) obtained from bovine teeth that have polished surfaces and no obliterated dentinal tubules will be made. The dentin blocks (n=120), randomly distributed, will be subjected to mechanical brushing with toothpaste: placebo (no F and no TMP), 1100 ppm F without TMP, 1100 ppm F associated with 3% TMP conventional, 1100 ppm F associated with 3% TMP nanoparticulate. This treatment is repeated twice a day for 7 days, with and without the acid challenge. At the end of the treatments will be analyzed mineral content, the obliteration of dentinal tubules using scanning electron microscopy, the identification and quantification of chemical elements present in the dentinal tubules deposits using energy dispersive X-ray (EDX) analysis and dentin permeability. Statistical analysis will be considered as variables: the mineral content, obliteration of the dentinal tubules, the content of chemical elements and dentin conductance. The variation factor will be the toothpaste. After the tests of normality and homogeneity of variances, will apply appropriate statistical test (p<0.05). For the chemical elements the analysis will be only descriptive. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FAVRETTO, CARLA OLIVEIRA; BOTAZZO DELBEM, ALBERTO CARLOS; SILOS MORAES, JOAO CARLOS; CAMARGO, EMERSON RODRIGUES; ALVES DE TOLEDO, PRISCILA TONINATTO; PEDRINI, DENISE. Dentinal tubule obliteration using toothpastes containing sodium trimetaphosphate microparticles or nanoparticles. CLINICAL ORAL INVESTIGATIONS, v. 22, n. 9, p. 3021-3029, DEC 2018. (13/25531-9)

FAVRETTO, CARLA OLIVEIRA; BOTAZZO DELBEM, ALBERTO CARLOS; ALVES TOLEDO, PRISCILA TONINATTO; PEDRINI, DENISE. Hydraulic conductance of dentin after treatment with fluoride toothpaste containing sodium trimetaphosphate microparticles or nanoparticles. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 4, AUG 2020. (13/25531-9)