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Study of pathogenic mechanisms and correlation with antimicrobial resistance of Klebsiella pneumoniae from Brazil and other countries across five continents

Abstract

Klebsiella pneumoniae, one of the most important opportunistic pathogens, can cause nosocomial infections, especially in immunocompromised individuals. The infections caused by this pathogen can cause several clinical complications, including urinary tract infections, pneumonia, sepsis and, in many cases, the death of patients. The establishment of the infection caused by K. pneumoniae is primarily due to their virulence factors. Moreover, the antimicrobial resistance presented by this specie has become a public health problem worldwide in recent years. Therefore, there is an increasing concern about the spread of K. pneumoniae harboring virulence factors and antimicrobial resistance, mainly in hospitals. In this way, the elucidation of the different mechanisms associated with virulence factors and resistance of K. pneumoniae that cause nosocomial infections are extremely important. The purpose of this project is to investigate the pathogenic potential, the antimicrobial resistance, the mobile genetic elements and to establish the molecular epidemiology of 150 K. pneumoniae, non-repetitive, isolated from patients admitted to different hospitals from all Brazilian regions and from countries of the five continents. In the literature, there are few Brazilian studies associating the pathogenicity of K. pneumoniae with antimicrobial resistance and epidemiological studies. Therefore, it is expected the results will contribute to the knowledge regarding to virulence, resistance and epidemiology of K. pneumoniae, providing subsidies that will allow better control and prevention of nosocomial infections. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, ROUMAYNE L.; REZENDE, GRAZIELA S.; FOLHAS DAMAS, MARCELO SILVA; OLIVEIRA-SILVA, MARIANA; PITONDO-SILVA, ANDRE; BRITO, MARCIA C. A.; LEONARDECZ, EDUARDO; DE GOES, FABIANA R.; CAMPANINI, EMELINE BONI; MALAVAZI, IRAN; DA CUNHA, ANDERSON F.; PRANCHEVICIUS, MARIA-CRISTINA DA SILVA. Characterization of KPC-Producing Serratia marcescens in an Intensive Care Unit of a Brazilian Tertiary Hospital. FRONTIERS IN MICROBIOLOGY, v. 11, MAY 20 2020. Web of Science Citations: 0.
ALVES AZEVEDO, PAOLA APARECIDA; RUEDA FURLAN, JOAO PEDRO; GONCALVES, GUILHERME BARTOLOMEU; GOMES, CAROLINA NOGUEIRA; GOULART, RAFAEL DA SILVA; STEHLING, ELIANA GUEDES; PITONDO-SILVA, ANDRE. Molecular characterisation of multidrug-resistant Klebsiella pneumoniae belonging to CC258 isolated from outpatients with urinary tract infection in Brazil. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v. 18, p. 74-79, SEP 2019. Web of Science Citations: 1.
NAVA, ROSEANE GALDIOLI; OLIVEIRA-SILVA, MARIANA; NAKAMURA-SILVA, RAFAEL; PITONDO-SILVA, ANDRE; VESPERO, ELIANA CAROLINA. New sequence type in multidrug-resistant Klebsiella pneumoniae harboring the bla(NDM-1)-encoding gene in Brazil. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v. 79, p. 101-103, FEB 2019. Web of Science Citations: 1.
FERREIRA, ROUMAYNE L.; DA SILVA, BRENDA C. M.; REZENDE, GRAZIELA S.; NAKAMURA-SILVA, RAFAEL; PITONDO-SILVA, ANDRE; CAMPANINI, EMELINE BONI; BRITO, MARCIA C. A.; DA SILVA, EULALIA M. L.; DE MELO FREIRE, CAIO CESAR; DA CUNHA, ANDERSON F.; DA SILVA PRANCHEVICIUS, MARIA-CRISTINA. High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and beta-Lactamase Encoding Genes in a Brazilian Intensive Care Unit. FRONTIERS IN MICROBIOLOGY, v. 9, JAN 22 2019. Web of Science Citations: 7.
DE CAMPOS, TATIANA AMABILE; GONCALVES, LAURA FERNANDES; MAGALHAES, KELLY GRACE; MARTINS, VICENTE DE PAULO; PAPPAS JUNIOR, GEORGIOS JOANNIS; PEIRANO, GISELE; PITOUT, JOHANN D. D.; GONCALVES, GUILHERME BARTOLOMEU; RUEDA FURLAN, JOAO PEDRO; STEHLING, ELIANA GUEDES; PITONDO-SILVA, ANDRE. A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil. FRONTIERS IN MEDICINE, v. 5, SEP 21 2018. Web of Science Citations: 2.
PAOLA APARECIDA ALVES AZEVEDO; JOÃO PEDRO RUEDA FURLAN; MARIANA OLIVEIRA-SILVA; RAFAEL NAKAMURA-SILVA; CAROLINA NOGUEIRA GOMES; KAREN REGINA CARIM COSTA; ELIANA GUEDES STEHLING; ANDRÉ PITONDO-SILVA. Detection of virulence and β-lactamase encoding genes in Enterobacter aerogenes and Enterobacter cloacae clinical isolates from Brazil. Brazilian Journal of Microbiology, v. 49, p. -, 2018.
ALVES AZEVEDO, PAOLA APARECIDA; RUEDA FURLAN, JOAO PEDRO; OLIVEIRA-SILVA, MARIANA; NAKAMURA-SILVA, RAFAEL; GOMES, CAROLINA NOGUEIRA; CARIM COSTA, KAREN REGINA; STEHLING, ELIANA GUEDES; PITONDO-SILVA, ANDRE. Detection of virulence and beta-lactamase encoding genes in Enterobacter aerogenes and Enterobacter cloacae clinical isolates from Brazil. Brazilian Journal of Microbiology, v. 49, n. 1, p. 224-228, 2018. Web of Science Citations: 2.
GONCALVES, GUILHERME BARTOLOMEU; RUEDA FURLAN, JOAO PEDRO; VESPERO, ELIANA CAROLINA; PELISSON, MARSILENI; STEHLING, ELIANA GUEDES; PITONDO-SILVA, ANDRE. Spread of multidrug-resistant high-risk Klebsiella pneumoniae clones in a tertiary hospital from southern Brazil. INFECTION GENETICS AND EVOLUTION, v. 56, p. 1-7, DEC 2017. Web of Science Citations: 7.

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