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In situ evaluation of the anti-erosive effect of solutions containing sodium fluoride, stannous chloride and linear chain sodium polyphosphate

Grant number: 14/14055-4
Support type:Regular Research Grants
Duration: February 01, 2015 - January 31, 2017
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Taís Scaramucci Forlin
Grantee:Taís Scaramucci Forlin
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Anderson Takeo Hara ; Patricia Moreira de Freitas Costa e Silva


The aim of this study is to evaluate the anti-erosive effect of solutions containing sodium fluoride (225 ppm F), sodium fluoride + stannous chloride (F+Sn: 225 ppm F + 800 ppm Sn), sodium fluoride + stannous chloride + linear chain sodium polyphosphate (F+Sn+LPP: 225 ppm F + 800 ppm Sn + 2% LPP) and deionized water (negative control), using a four-phase, single-blind crossover in situ clinical trial. Twelve volunteers (who meet the inclusion/exclusion criteria) will participate in this study after signing the term of inform consent. In each phase, volunteers will use mandible appliances containing 4 specimens of flat and polished enamel, which will undergo a 5-day erosion-remineralization cycle, consisting of extra-oral immersion in 0,5% citric acid (pH 2,6) for 2 min, 6x/day, with 1.5 h of exposure to saliva in situ between the challenges. Treatment with the test solutions will be performed extra-orally for 2 min, 2x/day, 75 min after first and last erosive challenges. In the end of the experiment, enamel surface loss (in µm) will be evaluated with optical profilometry. For a better understanding of the interaction between the tested substances with the enamel surface, additional specimens will be prepared and treated with the experimental solutions for 2 min (n=3). Then, the surface of these specimens will be characterized by x-ray diffraction. Surface loss data of each volunteer, in each phase, will be analyzed by appropriate statistical tests. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, L. G. S.; JOAO-SOUZA, S. H.; BEZERRA, S. J. C.; BORGES, A. B.; ARANHA, A. C. C.; SCARAMUCCI, T. Nd:YAG laser irradiation associated with fluoridated gels containing photo absorbers in the prevention of enamel erosion. Lasers in Medical Science, v. 32, n. 7, p. 1453-1459, SEP 2017. Web of Science Citations: 3.
JOAO-SOUZA, SAMIRA HELENA; BEZERRA, SAVIO JOSE C.; DE FREITAS, PATRICIA MOREIRA; DE LIMA, NELSON B.; CORREA ARANHA, ANA CECILIA; HARA, ANDERSON T.; SCARAMUCCI, TAIS. In situ evaluation of fluoride-, stannous-and polyphosphate-containing solutions against enamel erosion. Journal of Dentistry, v. 63, p. 30-35, AUG 2017. Web of Science Citations: 6.
JOAO-SOUZA, SAMIRA HELENA; CARDOSO BEZERRA, SAVIO JOSE; BORGES, ALESSANDRA BUEHLER; ARANHA, ANA CECILIA; SCARAMUCCI, TAIS. Effect of sodium fluoride and stannous chloride associated with Nd:YAG laser irradiation on the progression of enamel erosion. Lasers in Medical Science, v. 30, n. 9, p. 2227-2232, DEC 2015. Web of Science Citations: 5.

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