Influence of zinc, copper and superoxide dismutase 1 polymorphism on mortality in patients with septic shock

• Grant number: 14/17262-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2015
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcos Ferreira Minicucci
• Grantee: Marcos Ferreira Minicucci
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Leonardo Antonio Mamede Zornoff ; Paula Schmidt Azevedo Gaiolla ; Sergio Alberto Rupp de Paiva

Abstract

Despite advances in the knowledge of septic shock in the last decades, it continuous to be the leading cause of death in intensive care units. Oxidative stress is increasingly recognized as a key feature of septic shock, and as an interesting therapeutic target. In critically ill patients low plasma zinc (Zn) concentrations and higher levels of copper (Cu) were observed due to the inflammatory process, as well as, reduced activity of enzymatic antioxidant defense systems. Superoxide dismutase 1 (SOD1) is one of the main enzymes, in the human body, responsible for combating oxidative stress. Its antioxidant capacity is influenced by plasma Zn and Cu concentrations. In addition, the A35C and G2809A SOD1 polymorphisms also appears to influence the activity of the enzyme. Studies investigating the association between the activity of SOD1 and A35C and G2809A polymorphisms are controversial. However, some studies showed that the presence of polymorphisms were associated with lower activity of SOD1 and consequently with increased oxidative stress. In patients with septic shock the associations between A35C and G2809A polymorphisms of SOD1 gene, its enzymatic activity and nutritional status of Zn and Cu have not yet been studied.Therefore, the aim of this study is to evaluate the influence of Zn, Cu, A35C and G2809A polymorphisms of SOD1 in the activity of this enzyme and mortality in patients with septic shock. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; MAGALHAES, ELOA SIQUEIRA; WATANABE ISHIKAWA, LARISSA LUMI; SIQUEIRA BRUDER, RITA DE CASSIA; DA SILVA, EVELYN APARECIDA; GONCALVES, RENAN BRAGA; TANNI, SUZANA ERICO; et al. Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 22, n. 10, p. 4732-4737, OCT 2018. (14/17262-0, 14/07988-4)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; HENRIQUE FERNANDES, ANA ANGELICA; POLEGATO, BERTHA FURLAN; CUNHA, NATALIA BARALDI; BACHIEGA, TATIANA FERNANDA; MARTINS LOURENCO, MARIA ANGELICA; FAVERO JUNIOR, EDSON LUIZ; MAMEDE ZORNOFF, LEONARDO ANTONIO; et al. Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock. JOURNAL OF INTENSIVE CARE MEDICINE, v. 34, n. 8, p. 669-673, AUG 2019. (14/17262-0)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; TANNI, SUZANA ERICO; CUNHA, NATALIA BARALDI; HENRIQUE FERNANDES, ANA ANGELICA; POLEGATO, BERTHA FURLAN; MAMEDE ZORNOFF, LEONARDO ANTONIO; RUPP DE PAIVA, SERGIO ALBERTO; BALBI, ANDRE LUIS; et al. Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury. BIOSCIENCE REPORTS, v. 38, p. 8-pg., 2018-02-28. (14/17262-0)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; TANNI, SUZANA ERICO; CUNHA, NATALIA BARALDI; HENRIQUE FERNANDES, ANA ANGELICA; POLEGATO, BERTHA FURLAN; MAMEDE ZORNOFF, LEONARDO ANTONIO; RUPP DE PAIVA, SERGIO ALBERTO; BALBI, ANDRE LUIS; et al. Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury. BIOSCIENCE REPORTS, v. 38, n. 1, FEB 28 2018. (14/17262-0)

NARA ALINE COSTA; BERTHA FURLAN POLEGATO; AMANDA GOMES PEREIRA; SÉRGIO ALBERTO RUPP DE PAIVA; ANA LÚCIA GUT; ANDRÉ LUÍS BALBI; DANIELA PONCE; LEONARDO ANTONIO MAMEDE ZORNOFF; PAULA SCHMIDT AZEVEDO; MARCOS FERREIRA MINICUCCI. Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury. Revista da Associação Médica Brasileira, v. 66, n. 11, p. 1515-1520, 2020-12-02. (14/17262-0, 14/07988-4)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; TANNI, SUZANA ERICO; CUNHA, NATALIA BARALDI; MAGALHAES, ELOA SIQUEIRA; SILVA, GRAZIELA BIUDE; POLEGATO, BERTHA FURLAN; MAMEDE ZORNOFF, LEONARDO ANTONIO; RUPP DE PAIVA, SERGIO ALBERTO; et al. Erythrocyte superoxide dismutase as a biomarker of septic acute kidney injury. ANNALS OF INTENSIVE CARE, v. 6, OCT 6 2016. (14/17262-0)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; MAGALHAES, ELOA SIQUEIRA; WATANABE ISHIKAWA, LARISSA LUMI; SIQUEIRA BRUDER, RITA DE CASSIA; DA SILVA, EVELYN APARECIDA; GONCALVES, RENAN BRAGA; TANNI, SUZANA ERICO; et al. Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 22, n. 10, p. 6-pg., 2018-10-01. (14/17262-0, 14/07988-4)

COSTA, NARA ALINE; CUNHA, NATALIA BARALDI; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; MAMEDE ZORNOFF, LEONARDO ANTONIO; RUPP DE PAIVA, SERGIO ALBERTO; REIS, BRUNA ZAVARIZE; HENRIQUE FERNANDES, ANA ANGELICA; ROGERO, MARCELO MACEDO; et al. Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock. Free Radical Biology and Medicine, v. 124, p. 199-204, AUG 20 2018. (14/17262-0, 14/07988-4)

PEREIRA, AMANDA GOMES; COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; TANNI, SUZANA ERICO; ZORNOFF, LEONARDO ANTONIO MAMEDE; DE PAIVA, SERGIO ALBERTO RUPP; POLEGATO, BERTHA FURLAN; MINICUCCI, MARCOS FERREIRA. Urea to albumin ratio is a predictor of mortality in patients with septic shock. CLINICAL NUTRITION ESPEN, v. 42, p. 361-365, APR 2021. (17/21554-5, 14/17262-0)