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Study of zoonotic visceral leishmaniasis expansion in the State of São Paulo and evaluation of control actions in Araçatuba and Birigüi cities

Grant number: 14/17764-6
Support type:Regular Research Grants
Duration: March 01, 2015 - February 28, 2017
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Francisco Chiaravalloti Neto
Grantee:Francisco Chiaravalloti Neto
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Caris Maroni Nunes ; Cláudia Torres Codeço ; Lilian Aparecida Colebrusco Rodas ; Margareth Regina Dibo ; Marluci Monteiro Guirado ; Rossana Verónica Mendoza López ; Vera Lucia Fonseca de Camargo Neves


The visceral leishmaniasis is the most severe clinical form of leishmaniasis and is considered an emerging disease by the World Health Organization. In São Paulo, the first autochthonous case was detected in 1998, in the same way that expansion occurs into urban areas all over Brazil since the 1980s, the visceral leishmaniasis has expanded to other municipalities' urban areas of the São Paulo, representing a major problem public health. Studies have linked the spread of vector with the construction of highways and railroads, and there are indications that human disease is associated with the occurrence of canine cases. One of the main strategies to control the disease is culling infected dogs. However, despite efforts to control, the disease's incidence remains high in Brazil. In this context, we intend to investigate the association between the expansion of vector and disease with highways and railroads of São Paulo and the construction of the gas pipeline Bolivia - Brazil during 1997-2013; With data from a serological survey and capture-mark-recapture experiments in dog populations, respectively, domiciled and community, adapt dynamics models of the canine disease transmission in order to point out the socio-demographic differences in applications of control measures among municipalities of Araçatuba and Birigüi; And through analysis of cost-effectiveness associated with dynamic models, check the best control effort at the lowest possible cost. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, AGDA M.; LOPEZ, ROSSANA V. M.; DIBO, MARGARETH R.; RODAS, LILIAN A. C.; GUIRADO, MARLUCI M.; CHIARAVALLOTI-NETO, FRANCISCO. Dispersion of Lutzomyia longipalpis and expansion of visceral leishmaniasis in Sao Paulo State, Brazil: identification of associated factors through survival analysis. PARASITES & VECTORS, v. 11, SEP 10 2018. Web of Science Citations: 0.
MORALEJO BERMUDI, PATRICIA MARQUES; GUIRADO, MARLUCI MONTEIRO; COLEBRUSCO RODAS, LILIAN APARECIDA; DIBO, MARGARETH REGINA; CHIARAVALLOTI-NETO, FRANCISCO. Spatio-temporal analysis of the occurrence of human visceral leishmaniasis in Aracatuba, State of Sao Paulo, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 452-460, JUL-AUG 2018. Web of Science Citations: 1.

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