Effects of okra and/or exercise training in animals with metabolic syndrome.

• Grant number: 15/19893-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2016
• End date: January 31, 2018
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Alessandra Medeiros
• Grantee: Alessandra Medeiros
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Claudia Maria da Penha Oller do Nascimento ; Debora Estadella ; João Henrique Ghilardi Lago ; Patricia Chakur Brum

Abstract

Metabolic Syndrome (MS) is a set of metabolic disorders, which may involve hyperglycemia, insulin resistance and dyslipidemia. Commonly presents associated with type 2 diabetes and hypertension, but can also be associated with other cardiovascular diseases. In MS there is an impairment of several organ and systems such as cardiovascular, hepatic, pancreatic, among others. Recently okra was identified as hypoglycemic and antioxidant, suggesting that their action can contribute to energy homeostasis in experimental models of MS. The exercise training (ET) has been suggested as an important tool for prevention and/or treatment of MS. Among its effects already elucidated we can highlight the improvement of energy metabolism and glucose control. Based on this information this project was conceived in order to identify the phytochemical profile of okra that will be used and, from there, to characterize the therapeutic effects of okra, associated or not to ET in animals with MS. After the identification of effects, we intend to investigate the signaling pathways related to the effects found. To achieve the aforementioned objectives will be analyzed biochemical, morphological, metabolic and clinical aspects. Liver, soleus and plantar muscles, left ventricle, adipose tissue and blood serum will be investigated. Statistical analysis will be used Statistica program and the results are expressed as mean ± standard error of the mean and analyzed by Student's t test unpaired ANOVA one or two routes when necessary. In all the results presented will be adopted as 5% threshold for statistical significance (p <0.05). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASAGRANDE, B. P.; GOMES, M. F. P.; MOURA, E. O. C.; SANTOS, A. C. C.; KUBOTA, M. C.; RIBEIRO, D. A.; PISANI, L. P.; MEDEIROS, A.; ESTADELLA, D.. Age-dependent hepatic alterations induced by a high-fat high-fructose diet. Inflammation Research, v. 68, n. 5, p. 359-368, MAY 2019. (15/19893-0)

DA SILVA, MONIQUE MARQUES; PEREIRA GOMES, MOISES FELIPE; CARVALHO DE MOURA, ELIZABETH DE ORLEANS; VERAS, MARIANA MATERA; KUBOTA, MELINA CHIEMI; TAKANO, ANA PAULA; CARDOSO DOS SANTOS, ANA CAROLINA; DOS REIS JOSE, CAROLINA GONCALVES; DA SILVA SOUZA, GRAZIELE APARECIDA; CARDOSO, NAIARA MAGALHAES; et al. Aerobic exercise training combined or not with okra consumption as a strategy to prevent kidney changes caused by metabolic syndrome in Zucker rats. PLoS One, v. 17, n. 6, p. 21-pg., 2022-01-01. (15/19893-0)

GOMES, MOISES FELIPE PEREIRA; DE MOURA, ELIZABETH DE ORLEANS CARVALHO; CARDOSO, NAIARA MAGALHAES; DA SILVA, GRAZIELE APARECIDA; DOS SANTOS, ANA CAROLINA CARDOSO; DE SOUZA, FERNANDA SAMANTHA; ESTADELLA, DEBORA; LAMBERTUCCI, RAFAEL HERLING; LAGO, JOAO HENRIQUE GHILARDI; MEDEIROS, ALESSANDRA. Supplementation with okra combined or not with exercise training is able to protect the heart of animals with metabolic syndrome. SCIENTIFIC REPORTS, v. 13, n. 1, p. 11-pg., 2023-01-26. (15/19893-0)