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Effects of okra and/or exercise training in animals with metabolic syndrome

Grant number: 15/19893-0
Support type:Regular Research Grants
Duration: February 01, 2016 - January 31, 2018
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Alessandra Medeiros
Grantee:Alessandra Medeiros
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Assoc. researchers:Claudia Maria da Penha Oller Do Nascimento ; Debora Estadella ; João Henrique Ghilardi Lago ; Patricia Chakur Brum


Metabolic Syndrome (MS) is a set of metabolic disorders, which may involve hyperglycemia, insulin resistance and dyslipidemia. Commonly presents associated with type 2 diabetes and hypertension, but can also be associated with other cardiovascular diseases. In MS there is an impairment of several organ and systems such as cardiovascular, hepatic, pancreatic, among others. Recently okra was identified as hypoglycemic and antioxidant, suggesting that their action can contribute to energy homeostasis in experimental models of MS. The exercise training (ET) has been suggested as an important tool for prevention and/or treatment of MS. Among its effects already elucidated we can highlight the improvement of energy metabolism and glucose control. Based on this information this project was conceived in order to identify the phytochemical profile of okra that will be used and, from there, to characterize the therapeutic effects of okra, associated or not to ET in animals with MS. After the identification of effects, we intend to investigate the signaling pathways related to the effects found. To achieve the aforementioned objectives will be analyzed biochemical, morphological, metabolic and clinical aspects. Liver, soleus and plantar muscles, left ventricle, adipose tissue and blood serum will be investigated. Statistical analysis will be used Statistica program and the results are expressed as mean ± standard error of the mean and analyzed by Student's t test unpaired ANOVA one or two routes when necessary. In all the results presented will be adopted as 5% threshold for statistical significance (p <0.05). (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASAGRANDE, B. P.; GOMES, M. F. P.; MOURA, E. O. C.; SANTOS, A. C. C.; KUBOTA, M. C.; RIBEIRO, D. A.; PISANI, L. P.; MEDEIROS, A.; ESTADELLA, D. Age-dependent hepatic alterations induced by a high-fat high-fructose diet. Inflammation Research, v. 68, n. 5, p. 359-368, MAY 2019. Web of Science Citations: 0.

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